[Treatment of endometrial carcinoma].

Abstract

The mainstay of the initial treatment for endometrial carcinoma is surgery with total hysterectomy and bilateral salpingo-oophorectomy. Pelvic-aortic lymphadenectomy may be appropriate for patients having tumors with a high risk for extrauterine spread. Most importantly, these include carcinomas with deep (≥ 50%) myometrial invasion, poor differentiation, or nonendometrioid histology, in which lymphadenectomy aids in prognostication and tailoring of adjuvant treatments. Vaginal cuff brachytherapy ensures vaginal control in stage I endometrioid carcinomas with high-risk features. For advanced carcinomas, chemotherapy is the adjuvant treatment of choice, combined with whole pelvic external beam radiotherapy in selected cases.

• Authors: Mikko Loukovaara, Anna Luomaranta, Arto Leminen
• Journal: Duodecim; laaketieteellinen aikakauskirja (Duodecim) Vol. 130 Issue 22-23 Pg. 2348-55 ( 2014) ISSN: 0012-7183 [Print] Finland
• Vernacular Title: Kohdunrunkosyövän hoito.
• PMID: 25558597 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (therapeutic use)
• Brachytherapy (methods)
• Endometrial Neoplasms (pathology, therapy)
• Female
• Humans
• Hysterectomy
• Lymph Node Excision
• Neoplasm Invasiveness
• Neoplasm Staging
• Ovariectomy
• Salpingectomy