Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3).

Abstract

BACKGROUND:

Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH)D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.

METHODS:

SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25(OH)D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.

RESULTS:

We found no association between any of the four SNPs or their polygenic score and breast cancer risk.

CONCLUSIONS:

Our findings do not support an association between vitamin D status, as reflected by 25(OH)D-related genotypes, and breast cancer risk.

IMPACT:

These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer. Cancer Epidemiol Biomarkers Prev; 24(3); 627-30. ©2014 AACR.

• Authors: Alison M Mondul, Irene M Shui, Kai Yu, Stephanie J Weinstein, Konstantinos K Tsilidis, Amit D Joshi, Antonio Agudo, Christine D Berg, Amanda Black, Julie E Buring, Daniel I Chasman, Mia M Gaudet, Christopher Haiman, Susan E Hankinson, Brian E Henderson, Robert N Hoover, David J Hunter, Kay-Tee Khaw, Tilman Kühn, Marina Kvaskoff, Loic Le Marchand, Sara Lindström, Marjorie L McCullough, Kim Overvad, Petra H Peeters, Elio Riboli, Paul M Ridker, Daniel O Stram, Malin Sund, Dimitrios Trichopoulos, Rosario Tumino, Elisabete Weiderpass, Walter Willett, Peter Kraft, Regina G Ziegler, Demetrius Albanes
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 24 Issue 3 Pg. 627-30 (Mar 2015) ISSN: 1538-7755 [Electronic] United States
• PMID: 25542828 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: ©2014 American Association for Cancer Research.

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Breast Neoplasms (epidemiology, genetics, metabolism)
• Cohort Studies
• Female
• Genetic Predisposition to Disease
• Genetic Variation
• Genome-Wide Association Study (methods)
• Humans
• Male
• Polymorphism, Single Nucleotide
• Prostatic Neoplasms (epidemiology, genetics, metabolism)
• Vitamin D (analogs & derivatives, genetics, metabolism)