[Detection of circulating tumor cells and its clinical value for different stages and various subtypes of breast cancer].

Abstract

OBJECTIVE:

To explore the prognostic value of applying a semi-automated detection system for detecting circulating tumor cells (CTC) for different stages and various subtypes of breast cancer.

METHODS:

Immunomagnetic separation and immunofluorescent staining were employed to detect the expressions of CTC and CTC HER-2. Chi-square test, univariate and multivariate analyses were used to examine the correlations between CTC and clinical characteristics.

RESULTS:

CTC was detected in 57.5% (138/240) of metastatic breast cancer (MBC). CTC enumeration, HER-2 status, number of metastasis and bone metastasis were relevant (P < 0.05). CTC was detected in 23.1% (6/26) of early-stage breast cancer (EBC). CTC enumeration, pathological type, estrogen receptor (ER), progesterone receptor (PR), Ki-67, tumor size and lymph node metastasis were irrelevant (P > 0.05). HER-2-positive MBC detected less CTC than HER-2-negative (χ(2) = 12.296, P < 0.001) . CTC HER-2 expression was different between HER-2-positive and negative patients in 99 MBC cases (χ(2) = 8.082, P = 0.004).

CONCLUSION:

CTC enumeration is different for various stages and different subtypes of breast cancer. CTC enumeration and bone metastasis are relevant. CTC detection in EBC may predict tumor relapse. And CTC HER-2 expression is different between HER-2-positive and negative MBC patients.

• Authors: Lei Li, Yi Liu, Shaohua Zhang, Tao Wang, Li Bian, Shikai Wu, Santai Song, Bing Liu, Zefei Jiang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 94 Issue 36 Pg. 2812-5 (Sep 30 2014) ISSN: 0376-2491 [Print] China
• PMID: 25534097 (Publication Type: Journal Article)

Chemical References

• Receptors, Estrogen
• Receptors, Progesterone
• ERBB2 protein, human
• Receptor, ErbB-2

Topics

• Bone Neoplasms
• Breast Neoplasms
• Humans
• Lymphatic Metastasis
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Neoplastic Cells, Circulating
• Prognosis
• Receptor, ErbB-2
• Receptors, Estrogen
• Receptors, Progesterone