Abstract |
Radiation-induced lung injury (RILI) is a frequent, sometimes life-threatening complication of radiation therapy for the treatment of lung cancer. The anti-inflammatory role of ulinastatin has been well documented, and the potential application of ulinastatin in management of acute lung injury has been suggested in multiple animal studies. In this article, we described a double-blind, randomized, placebo-controlled study in patients with non-small cell lung cancer. A total of 120 patients were randomized into two groups: the trial group was treated with ulinastatin for 3 days prior to and for the first 7 days of radiation therapy and the control group was treated with placebo for 10 days following the same schedule. The results from follow-up studies showed that the incidence and grade of RILI were significantly lower in the trial group than in the control group. Reduction in pulmonary function from baseline was significantly smaller in the trial group than that in the control group. Production of serum TGF-β1, TNF-α and IL-6 decreased significantly in the trial group promptly following radiation therapy. However, no difference in survival or tumour response rate was found between the two groups. The results indicated that ulinastatin exerted a protective effect on radiation-induced lung injury. Treatment with ulinastatin could be an effective management strategy and greatly improve the clinical efficacy of radiation therapy for patients with lung cancer.
|
Authors | Pengtao Bao, Weiguo Zhao, Yun Li, Yu Liu, Yi Zhou, Changting Liu |
Journal | Medical oncology (Northwood, London, England)
(Med Oncol)
Vol. 32
Issue 1
Pg. 405
(Jan 2015)
ISSN: 1559-131X [Electronic] United States |
PMID | 25502081
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Glycoproteins
- Trypsin Inhibitors
- urinastatin
|
Topics |
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
(mortality, radiotherapy)
- Double-Blind Method
- Female
- Glycoproteins
(therapeutic use)
- Humans
- Kaplan-Meier Estimate
- Lung Neoplasms
(mortality, radiotherapy)
- Male
- Middle Aged
- Radiation Pneumonitis
(prevention & control)
- Trypsin Inhibitors
(therapeutic use)
|