ShcC proteins: brain aging and beyond.

Abstract

To date, most studies of Shc family of signaling adaptor proteins have been focused on the near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and longevity. Although the role of the neuronal ShcC protein is much less investigated, accumulated evidence suggests its importance for neuroprotection against such aging-associated conditions as brain ischemia and oxidative stress. Here, we summarize more than decade of studies on the ShcC expression and function in normal brain, age-related brain pathologies and immune disorders with a focus on the interactions of ShcC with signaling proteins/pathways, and the possible implications of these interactions for changes associated with aging.

• Authors: Orli Sagi, Arie Budovsky, Marina Wolfson, Vadim E Fraifeld
• Journal: Ageing research reviews (Ageing Res Rev) Vol. 19 Pg. 34-42 (Jan 2015) ISSN: 1872-9649 [Electronic] England
• PMID: 25462193 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Shc Signaling Adaptor Proteins

Topics

• Aging (physiology)
• Animals
• Brain (growth & development)
• Brain Neoplasms (physiopathology)
• Humans
• Shc Signaling Adaptor Proteins (physiology)