Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice.

Abstract

Mucositis is a common problem that results from cancer chemotherapy and is a cause of significant morbidity and occasional mortality. Its prevention and successful treatment can significantly enhance the quality of life of patients and improve their survival. Sea cucumber is a traditional aquatic food that has both nutritional and medicinal value. The polysaccharide fucoidan from the sea cucumber (SC-FUC) has various bioactivities. We examined the protective effect of different molecular weights (MWs 50 kDa-500 kDa) of fucoidan from the sea cucumber, Acaudina molpadioides, in a mouse model of cyclophosphamide (Cy)-induced intestinal mucositis. Results showed that the oral administration of SC-FUC markedly reversed Cy-induced damage in the mice. The sea cucumber fucoidan notably increased the ratio of the length of the intestinal villus to the crypt depth and ameliorated the IFN-γ/IL-4 ratio that signifies Th1/Th2 immune balance. Moreover, all the fucoidans in this study enhanced the expression of IgA by accelerating the expression of IL-6 that is probably combined with IL-10. The differing effects of the varied molecular weights of fucoidan may be due to the difference in the efficiency of absorption. This is a novel study on the potential preventive effects of SC-FUC on intestinal mucositis that may be related to the efficiency of its absorption during digestion. Sea cucumber fucoidan (SC-FUC) may be used as a potential food supplement to prevent chemotherapeutic mucositis.

• Authors: Tao Zuo, Xuemin Li, Yaoguang Chang, Gaofei Duan, Long Yu, Rong Zheng, Changhu Xue, Qingjuan Tang
• Journal: Food & function (Food Funct) Vol. 6 Issue 2 Pg. 415-22 (Feb 2015) ISSN: 2042-650X [Electronic] England
• PMID: 25407449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Immunoglobulin A
• Interleukin-6
• Polysaccharides
• RNA, Messenger
• Interleukin-10
• Interleukin-4
• Fucose
• Interferon-gamma
• Cyclophosphamide
• fucoidan

Topics

• Animals
• Antineoplastic Agents (administration & dosage, adverse effects)
• Cyclophosphamide (administration & dosage, adverse effects)
• Disease Models, Animal
• Fucose (blood)
• Gene Expression Regulation
• Immunoglobulin A (metabolism)
• Interferon-gamma (metabolism)
• Interleukin-10 (metabolism)
• Interleukin-4 (metabolism)
• Interleukin-6 (metabolism)
• Intestinal Mucosa (drug effects, metabolism)
• Intestines (drug effects)
• Male
• Mice
• Mice, Inbred BALB C
• Molecular Weight
• Mucositis (chemically induced, prevention & control)
• Polysaccharides (administration & dosage)
• RNA, Messenger (metabolism)
• Sea Cucumbers (chemistry)