Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.

Abstract

A 47-year-old man was referred to our department due to multiple metastases in the lungs and liver with pleural dissemination six weeks after undergoing curative surgery for lung pleomorphic carcinoma. He received two regimens of chemotherapy, both of which resulted in disease progression. Considering his good general condition, he was treated with cisplatin plus gemcitabine (GP). The metastatic lesions exhibited a complete response after six courses of GP, and the patient has remained free from recurrence for over six years. An immunohistochemical analysis revealed that the tumor was highly expressive of gemcitabine transporter human equilibrative nucleoside transporter 1, thus suggesting a high sensitivity to gemcitabine.

• Authors: Akihiro Tamiya, Kazuhiro Asami, Shigeki Shimizu, Akihide Matsumura, Shun-Ichi Isa, Kyoichi Okishio, Masanori Kitaichi, Shinji Atagi, Minoru Takada, Tomoya Kawaguchi, Akihito Kubo
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 53 Issue 22 Pg. 2625-8 ( 2014) ISSN: 1349-7235 [Electronic] Japan
• PMID: 25400187 (Publication Type: Case Reports, Journal Article)

Chemical References

• Equilibrative Nucleoside Transporter 1
• SLC29A1 protein, human
• Deoxycytidine
• Cisplatin
• Gemcitabine

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma (drug therapy)
• Cisplatin (administration & dosage)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Equilibrative Nucleoside Transporter 1 (genetics)
• Humans
• Lung Neoplasms (drug therapy)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy)
• Remission Induction
• Gemcitabine