Validity of the European short list of respiratory diseases: a 40-year autopsy study.

Abstract

The predictors of autopsy and the accuracy of European short list (E) codes of respiratory diseases lack recent knowledge. A 10% random sample (n=6811) of inhabitants of Bergen, Norway, aged 20-70 years, was invited to participate in a survey in 1965-1971 (participation rate 83%). By December 31, 2005, 4387 (64%) participants had died and 1163 (27% of the deceased) had been given an autopsy. Causes of death were tuberculosis (E02, 0.2%), lung malignancy (E15, 3.5%), influenza (E38, 0.2%), pneumonia (E39, 6.5%) and chronic lower respiratory diseases (E40, 3.2%). Male sex, early deaths in the surveillance period and E15 were positive predictors of an autopsy examination, whereas old age and E39 were strong negative predictors. Among those referred for a post mortem examination, the cause of death was verified as tuberculosis in 0.3%, lung cancer in 8.1%, acute pneumonia in 2.0% and chronic obstructive lung diseases in 4.9%. Cohen's kappa coefficients (E codes versus autopsy) were 0.91 (95% CI 0.86-0.96) for E15, 0.37 (95% CI 0.20-0.54) for E39 and 0.65 (95% CI 0.54-0.76) for E40. These findings matter when deaths from respiratory diseases are used as end-points in epidemiological association studies and clinical trials.

• Authors: Anne K Gulsvik, Andreas H Henriksen, Einar Svendsen, Sjur Humerfelt, Amund Gulsvik
• Journal: The European respiratory journal (Eur Respir J) Vol. 45 Issue 4 Pg. 953-61 (Apr 2015) ISSN: 1399-3003 [Electronic] England
• PMID: 25359344 (Publication Type: Journal Article, Validation Study)
• Copyright: Copyright ©ERS 2015.

Topics

• Adult
• Age Factors
• Aged
• Autopsy
• Cause of Death
• Confidence Intervals
• Databases, Factual
• Europe
• Female
• Humans
• Male
• Middle Aged
• Mortality (trends)
• Norway
• Predictive Value of Tests
• Respiratory Tract Diseases (diagnosis, mortality, pathology)
• Retrospective Studies
• Risk Assessment
• Sex Factors
• Urban Population
• Young Adult