Abstract | BACKGROUND: METHODS: Unstimulated whole saliva samples, together with full-mouth periodontal recordings (plaque index [PI], bleeding on probing [BOP %], gingival index [GI], probing pocket depth [ PPD], and clinical attachment level [CAL]), were collected from 123 subjects with T2DM. Additionally, demographic and general health parameters, including fasting blood glucose, glycated hemoglobin (HbA1c), were collected. Salivary IL-17 and TNF-α concentrations were analyzed using the Luminex®-xMAP™ technique. RESULTS: Subjects with poorly-controlled T2DM (HbA1c ≥ 7) had elevated serum triglyceride (P < 0.001) concentration as well as elevated scores of BOP % (P = 0.014), PI (P = 0.048), GI (P = 0.033), and CAL (P = 0.003) in comparison to those of well-controlled T2DM (HbA1c < 7). When the subjects with detectable salivary IL-17 were categorized in tertiles, the scores of PPD and BOP%, and salivary TNF-α concentrations were significantly elevated in the highest (P = 0.007, P = 0.002 and P < 0.001, respectively) and middle (P = 0.052, P = 0.022, and P = 0.003, respectively) tertiles compared to subjects with non-detectable salivary IL-17. The adjusted association between PPD measurements and salivary IL-17 concentrations was significant (P = 0.008). CONCLUSIONS: Poorly-controlled glycemic status relates to the severity of periodontal disease in T2DM. The association between PPD and IL-17 in saliva, however, is independent from the effect of glycemic status.
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Authors | Ulvi Kahraman Gürsoy, Sinem Yildiz Çiftlikli, Eija Könönen, Mervi Gürsoy, Başak Doğan |
Journal | Journal of diabetes
(J Diabetes)
Vol. 7
Issue 5
Pg. 681-8
(Sep 2015)
ISSN: 1753-0407 [Electronic] Australia |
PMID | 25327309
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Interleukin-17
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(complications, drug therapy, metabolism)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Interleukin-17
(analysis)
- Male
- Middle Aged
- Periodontitis
(complications, metabolism)
- Saliva
(chemistry)
- Tumor Necrosis Factor-alpha
(analysis)
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