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Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer.

Abstract
Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal-Wallis and Dunn's tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3-1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3-1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed.
AuthorsMônica Ghislaine Oliveira Alves, Adriana da Mota Delgado, Ivan Balducci, Yasmin Rodarte Carvalho, Ana Sueli Rodrigues Cavalcante, Janete Dias Almeida
JournalArchives of dermatological research (Arch Dermatol Res) Vol. 306 Issue 9 Pg. 837-41 (Nov 2014) ISSN: 1432-069X [Electronic] Germany
PMID25241153 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • SUMO-1 Protein
  • SUMO1 protein, human
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
Topics
  • Adult
  • Aged
  • Biopsy
  • Carcinoma, Squamous Cell (enzymology, pathology)
  • Case-Control Studies
  • Cheilitis (enzymology, pathology)
  • Female
  • Humans
  • Immunohistochemistry
  • Lip Neoplasms (enzymology, pathology)
  • Male
  • Middle Aged
  • Mouth Mucosa (enzymology, pathology)
  • Proto-Oncogene Proteins c-mdm2 (analysis)
  • SUMO-1 Protein (analysis)
  • Up-Regulation

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