Abstract |
Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin- eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal-Wallis and Dunn's tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3-1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3-1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed.
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Authors | Mônica Ghislaine Oliveira Alves, Adriana da Mota Delgado, Ivan Balducci, Yasmin Rodarte Carvalho, Ana Sueli Rodrigues Cavalcante, Janete Dias Almeida |
Journal | Archives of dermatological research
(Arch Dermatol Res)
Vol. 306
Issue 9
Pg. 837-41
(Nov 2014)
ISSN: 1432-069X [Electronic] Germany |
PMID | 25241153
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- SUMO-1 Protein
- SUMO1 protein, human
- MDM2 protein, human
- Proto-Oncogene Proteins c-mdm2
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Topics |
- Adult
- Aged
- Biopsy
- Carcinoma, Squamous Cell
(enzymology, pathology)
- Case-Control Studies
- Cheilitis
(enzymology, pathology)
- Female
- Humans
- Immunohistochemistry
- Lip Neoplasms
(enzymology, pathology)
- Male
- Middle Aged
- Mouth Mucosa
(enzymology, pathology)
- Proto-Oncogene Proteins c-mdm2
(analysis)
- SUMO-1 Protein
(analysis)
- Up-Regulation
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