HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases.

Abstract
The X-box binding protein 1 (XBP1) is not only an important component of the unfolded protein response (UPR), but also an important nuclear transcription factor. Upon endoplasmic reticulum stress, XBP1 is spliced by inositol-requiring enzyme 1 (IRE1), thereby generating functional spliced XBP1 (XBP1s). XBP1s functions by translocating into the nucleus to initiate transcriptional programs that regulate a subset of UPR- and non-UPR-associated genes involved in the pathophysiological processes of various diseases. Recent reports have implicated XBP1 in metabolic diseases. This review summarizes the effects of XBP1-mediated regulation on lipid metabolism, glucose metabolism, obesity, and atherosclerosis. Additionally, for the first time, we present XBP1s-dependent transcriptional reprogramming in metabolic diseases under different conditions, including pathology and physiology. Understanding the function of XBP1 in metabolic diseases may provide a basic knowledge for the development of novel therapeutic targets for ameliorating these diseases.
AuthorsRong Wu, Qing-Hai Zhang, Yan-Ju Lu, Kun Ren, Guang-Hui Yi
JournalDNA and cell biology (DNA Cell Biol) Vol. 34 Issue 1 Pg. 6-18 (Jan 2015) ISSN: 1557-7430 [Electronic] United States
PMID25216212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • DNA-Binding Proteins
  • Regulatory Factor X Transcription Factors
  • Transcription Factors
  • X-Box Binding Protein 1
  • XBP1 protein, human
  • ERN1 protein, human
  • Protein Serine-Threonine Kinases
  • Endoribonucleases
  • Glucose
Topics
  • Animals
  • Cardiovascular Diseases (metabolism)
  • DNA-Binding Proteins (metabolism)
  • Diabetes Mellitus, Type 2 (metabolism)
  • Endoplasmic Reticulum Stress
  • Endoribonucleases (metabolism)
  • Gene Expression Regulation
  • Glucose (metabolism)
  • Humans
  • Lipid Metabolism
  • Obesity (metabolism)
  • Protein Serine-Threonine Kinases (metabolism)
  • Regulatory Factor X Transcription Factors
  • Transcription Factors (metabolism)
  • Transcription, Genetic
  • Unfolded Protein Response
  • X-Box Binding Protein 1

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: