Abstract |
The X-box binding protein 1 (XBP1) is not only an important component of the unfolded protein response (UPR), but also an important nuclear transcription factor. Upon endoplasmic reticulum stress, XBP1 is spliced by inositol-requiring enzyme 1 (IRE1), thereby generating functional spliced XBP1 (XBP1s). XBP1s functions by translocating into the nucleus to initiate transcriptional programs that regulate a subset of UPR- and non-UPR-associated genes involved in the pathophysiological processes of various diseases. Recent reports have implicated XBP1 in metabolic diseases. This review summarizes the effects of XBP1-mediated regulation on lipid metabolism, glucose metabolism, obesity, and atherosclerosis. Additionally, for the first time, we present XBP1s-dependent transcriptional reprogramming in metabolic diseases under different conditions, including pathology and physiology. Understanding the function of XBP1 in metabolic diseases may provide a basic knowledge for the development of novel therapeutic targets for ameliorating these diseases.
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Authors | Rong Wu, Qing-Hai Zhang, Yan-Ju Lu, Kun Ren, Guang-Hui Yi |
Journal | DNA and cell biology
(DNA Cell Biol)
Vol. 34
Issue 1
Pg. 6-18
(Jan 2015)
ISSN: 1557-7430 [Electronic] United States |
PMID | 25216212
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- DNA-Binding Proteins
- Regulatory Factor X Transcription Factors
- Transcription Factors
- X-Box Binding Protein 1
- XBP1 protein, human
- ERN1 protein, human
- Protein Serine-Threonine Kinases
- Endoribonucleases
- Glucose
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Topics |
- Animals
- Cardiovascular Diseases
(metabolism)
- DNA-Binding Proteins
(metabolism)
- Diabetes Mellitus, Type 2
(metabolism)
- Endoplasmic Reticulum Stress
- Endoribonucleases
(metabolism)
- Gene Expression Regulation
- Glucose
(metabolism)
- Humans
- Lipid Metabolism
- Obesity
(metabolism)
- Protein Serine-Threonine Kinases
(metabolism)
- Regulatory Factor X Transcription Factors
- Transcription Factors
(metabolism)
- Transcription, Genetic
- Unfolded Protein Response
- X-Box Binding Protein 1
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