Abstract | AIM: METHODS: A meta-analysis was conducted on data from older patients (≥65 years) from five of the GetGoal trials, in which patients with T2DM were treated with lixisenatide 20 µg once daily or placebo, as an add-on to OADs. The primary endpoint in all trials was change from baseline at week 24 in glycated hemoglobin (HbA1c). Other endpoints included changes in post-prandial plasma glucose (PPG), fasting plasma glucose (FPG) and weight. Composite and safety endpoints were also analyzed. RESULTS: A total of 501 patients aged ≥65 years were included in this meta-analysis: 304 received lixisenatide plus OADs and 197 received placebo as add-on to OADs. Lixisenatide as an add-on to OADs significantly reduced HbA1c, PPG, FPG and weight, with placebo-corrected treatment effects at week 24 of -0.54% (p<0.0001), -126 mg/dL (p<0.0001), -13 mg/dL (p=0.0005) and -0.90 kg (p=0.0021), respectively. Patients receiving lixisenatide plus OADs were significantly more likely to achieve composite (HbA1c levels<7%, HbA1c levels<7% and no symptomatic hypoglycemia, and HbA1c levels<7%, no weight gain and no symptomatic hypoglycemia) and safety endpoints than those receiving placebo plus OADs. Symptomatic hypoglycemia was experienced by 8.55% and 3.55% of patients in the lixisenatide plus OADs and placebo plus OADs groups, respectively (p=0.0276), although no serious hypoglycemic episodes were reported. CONCLUSIONS:
Lixisenatide plus OADs improved glycemic control in older patients inadequately controlled on OADs compared with placebo plus OADs. Lixisenatide is well tailored to the pathophysiology of T2DM in older patients.
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Authors | Markolf Hanefeld, Rachele Berria, Jay Lin, Ronnie Aronson, Patrice Darmon, Marc Evans, Luc Van Gaal |
Journal | Advances in therapy
(Adv Ther)
Vol. 31
Issue 8
Pg. 861-72
(Aug 2014)
ISSN: 1865-8652 [Electronic] United States |
PMID | 25143188
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Peptides
- lixisenatide
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Topics |
- Aged
- Blood Glucose
- Body Weight
- Diabetes Mellitus, Type 2
(drug therapy)
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Hypoglycemia
(chemically induced)
- Hypoglycemic Agents
(administration & dosage, adverse effects, therapeutic use)
- Male
- Peptides
(administration & dosage, adverse effects, therapeutic use)
- Postprandial Period
- Randomized Controlled Trials as Topic
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