Efficacy of two low-dose oral tylosin regimens in controlling the relapse of diarrhea in dogs with tylosin-responsive diarrhea: a prospective, single-blinded, two-arm parallel, clinical field trial.

Abstract

BACKGROUND:

Despite its wide acceptance as a treatment for canine chronic enteropathies, the macrolide antibiotic tylosin lacks official oral dosage recommendations. Not even textbooks share consensus about the dose; daily recommendations vary from 25 to 80 mg/kg and dosing intervals from one to three times daily.

RESULTS:

All eight dogs responded to the 5 mg/kg dose, and six of seven dogs responded to the 15 mg/kg dose. The mean fecal consistency scores at the 25 mg/kg tylosin dosage were no significantly different from scores at the 5 mg/kg or 15 mg/kg tylosin dosages (P=0.672, P=0.345).

CONCLUSIONS:

Interestingly, 14/15 (93%) of the dogs responding to a dose of 25 mg/kg tylosin once daily for seven days also responded to the lower dosages at diarrhea relapse. The data indicate that a suitable dose of tylosin for treating diarrhea relapse in canine TRD could be as low as 5 mg/kg once daily for seven days.

• Authors: Susanne Kilpinen, Thomas Spillmann, Elias Westermarck
• Journal: Acta veterinaria Scandinavica (Acta Vet Scand) Vol. 56 Pg. 43 (Aug 06 2014) ISSN: 1751-0147 [Electronic] England
• PMID: 25096196 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Tylosin

Topics

• Animals
• Anti-Bacterial Agents (therapeutic use)
• Chronic Disease (drug therapy)
• Diarrhea (drug therapy, microbiology, veterinary)
• Dog Diseases (drug therapy, microbiology)
• Dogs
• Dose-Response Relationship, Drug
• Female
• Male
• Prospective Studies
• Recurrence
• Secondary Prevention
• Single-Blind Method
• Tylosin (therapeutic use)