Tylosin

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127 relevant articles (23 outcomes, 16 trials/studies) found for this Bio-Agent

Description: Macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.

Also Known As:

Fradizine; Tylan; Tylosin Hydrochloride; Tylosin Tartrate (Salt); Tylosine; Hydrochloride, Tylosin

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 42

para-nitrobenzyl-oxime-tylosine: 1

10,11-dihydrodesmycosin

12,13-epoxydesmycosin

13-hydroxy-3-dehydroxy-3,12-oxa-desmycosin

19-deformyl-5-O-desosaminyl tylonide

19-deformyldesmycosin

2,3-didehydrodesmycosin

20-deoxorosaranolide

23-amino-O-mycaminosyltylonolide

23-O-benzyl-5-mycaminosyl-tylonolide

3,4'-dideoxy-5O-mycaminosyltylonolide

3-acetyl-4''-isovaleryltylosin

4''-O-(4-methoxyphenyl)acetyltylosin

4'-deoxy-10,11,12,13-tetrahydrodesmycosin

4'-deoxymycaminosyltylonolide

4'-dexydemycarosyltylosin

4-'demycarosyl-20-deoxo-20-(di-N-benzylamino)-8a-aza-8a-homotylosin

5-O-mycaminosylprotylonolide

micarosyl protylonolide

tylonolide hemiacetal

Polycyclic Compounds: 59

Macrocyclic Compounds: 2

para-nitrobenzyl-oxime-tylosine: 1

10,11-dihydrodesmycosin

12,13-epoxydesmycosin

13-hydroxy-3-dehydroxy-3,12-oxa-desmycosin

19-deformyl-5-O-desosaminyl tylonide

19-deformyldesmycosin

2,3-didehydrodesmycosin

20-deoxorosaranolide

23-amino-O-mycaminosyltylonolide

23-O-benzyl-5-mycaminosyl-tylonolide

3,4'-dideoxy-5O-mycaminosyltylonolide

3-acetyl-4''-isovaleryltylosin

4''-O-(4-methoxyphenyl)acetyltylosin

4'-deoxy-10,11,12,13-tetrahydrodesmycosin

4'-deoxymycaminosyltylonolide

4'-dexydemycarosyltylosin

4-'demycarosyl-20-deoxo-20-(di-N-benzylamino)-8a-aza-8a-homotylosin

5-O-mycaminosylprotylonolide

micarosyl protylonolide

tylonolide hemiacetal

para-nitrobenzyl-oxime-tylosine: 1

10,11-dihydrodesmycosin

12,13-epoxydesmycosin

13-hydroxy-3-dehydroxy-3,12-oxa-desmycosin

19-deformyl-5-O-desosaminyl tylonide

19-deformyldesmycosin

2,3-didehydrodesmycosin

20-deoxorosaranolide

23-amino-O-mycaminosyltylonolide

23-O-benzyl-5-mycaminosyl-tylonolide

3,4'-dideoxy-5O-mycaminosyltylonolide

3-acetyl-4''-isovaleryltylosin

4''-O-(4-methoxyphenyl)acetyltylosin

4'-deoxy-10,11,12,13-tetrahydrodesmycosin

4'-deoxymycaminosyltylonolide

4'-dexydemycarosyltylosin

4-'demycarosyl-20-deoxo-20-(di-N-benzylamino)-8a-aza-8a-homotylosin

5-O-mycaminosylprotylonolide

micarosyl protylonolide

tylonolide hemiacetal

Experts

1.	Skrzypczak, Teresa: 2 articles (11/2005 - 03/2005)
2.	Westermarck, Elias: 2 articles (11/2005 - 03/2005)
3.	McDougall, S: 1 article (02/2007)
4.	Agnew, K E: 1 article (02/2007)
5.	Compton, C R W: 1 article (02/2007)
6.	Cursons, R: 1 article (02/2007)
7.	Hou, X X: 1 article (02/2007)
8.	Keïta, A: 1 article (12/2006)
9.	Pagot, E: 1 article (12/2006)
10.	Neeve, S: 1 article (12/2006)

Related Diseases

1.	Infection 05/07/2005 - "Efficacy of in-feed medication with tylosin for the treatment and control of Mycoplasma hyopneumoniae infections." 07/01/1986 - "Prophylactic efficacy of 3-acetyl-4''-isovaleryl tylosin in a Mycoplasma gallisepticum-induced airsacculitis infection." 01/01/1996 - "Laboratory and field studies were conducted to determine the effectiveness of the antibiotic tylosin in preventing and controlling infections of American foulbrood disease (AFB) of honey bees. " 05/07/2005 - "Between 23 and 33 days after infection the mean respiratory disease score of the pigs treated with tylosin was 0.54 (0.22), significantly (P<0.05) lower than that of the infected pigs which were left untreated, 1.54 (0.46); similarly, their average lung lesion score, 1.72 (1.20), was significantly lower than that of the untreated pigs, 5.27 (3.85)." 12/01/2001 - "Administration of tylosin in feed at a concentration of 110 ppm for 14 days reduced the infection rate of the farms. " Order ALL the reference details at left...
2.	Liver Abscess 02/01/1994 - "In a second study, blood was collected at the time of slaughter from 141 feedlot cattle (36 fed diets with tylosin and 105 fed diets without tylosin), and livers were examined for presence or severity of hepatic abscesses at slaughter. " 07/01/2009 - "Prevalence of total liver abscesses was reduced for steers fed tylosin compared with no tylosin (P < 0.05). " 11/01/2008 - "A 2 x 2 factorial experiment with 48 crossbred steers (with Hereford, Angus, and Charolais genetics, and an initial BW of 373 +/- 8.4 kg) was conducted to evaluate the effects of dietary sunflower seeds (SS) and tylosin phosphate (TP) on production factors, carcass characteristics, liver abscess incidence, and fatty acid composition of the muscle (pars costalis diaphragmatis; PCD) and subcutaneous fat. " 11/01/2008 - "Effects of dietary sunflower seeds and tylosin phosphate on production variables, carcass characteristics, fatty acid composition, and liver abscess incidence in crossbred steers." 09/01/2008 - "Tylosin addition tended to decrease severity of liver abscesses in diets containing SFC, but not in diets containing WDGS. " Order ALL the reference details at left...
3.	Diarrhea 03/01/2005 - "Treatment with tylosin eliminated diarrhea in all dogs within 3 days and in most dogs within 24 hours. " 11/01/2005 - "We conclude that the combination of diet and tylosin was more effective than either agent alone in control of chronic diarrhea." 02/01/2008 - "This study evaluated the inflammatory changes in the colon of macaques with diarrhea and assessed the efficacy of a 10-d course of tylosin in a cohort of 21 animals with chronic diarrhea. " 01/01/2009 - "The antibiotic tylosin is often successfully used for the treatment of chronic diarrhea in dogs, but its exact mode of action and its effect on the intestinal microbiota remain unknown. " 02/01/2008 - "Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta)." Order ALL the reference details at left...
4.	Weight Gain 01/01/1983 - "Used in the same way with birds at the rates of 3, 5, and 10 per cent (equal to 450, resp., 750 and 1500 ppm with regard to tylosine in active matter) for a time period of 60 days the preparation did not lead to deviations in terms of the most clinical and morphological indices, however, it inhibited the weight gain by 3.2 to 8.1 per cent. " 01/01/1983 - "At prolonged application via the feed (30 days) in amounts of 0.5, 1.5, and 2.5 per cent (equal to 100, resp., 300 and 500 ppm with regard to tylosine in active matter) Pharmasine TB was shown to stimulate the weight gain on the basis of the better utilization of feed, having no unfavourable effect on the appetite, behaviour, clinical and biochemical composition of blood, and the morphologic structure of the viscera in pigs. " 05/01/1975 - "From the age of 56 days, the Tylan-application program provides statistically significant weight gains, as compared with other groups. " 01/01/2001 - "The challenged pigs had a positive treatment response to injectable tylosin compared with negative controls based on improvements in clinical signs, fecal polymerase chain reaction incidence on days 7 and 14, gross and microscopic intestinal lesions, average daily weight gain, and individual pig weight variation." 02/01/1975 - "Tylosin and chloretetracycline for the prevention of liver abscesses, improved weight gains and feed efficiency in feedlot cattle." Order ALL the reference details at left...
5.	Body Weight (Weight, Body) 10/01/2001 - "Tylosin at all levels provided improvement in Day 29 body weight, average daily gain, feed to gain ratio, and average daily feed intake compared to unmedicated birds. " 04/01/1986 - "Tylosin at 44 mg/kg changed to 22 mg/kg at 57 kg body weight caused an increase (P = .07) in rate of gain for the overall grower-finisher period and an improvement in feed efficiency in the grower (P = .07) and the grower-finisher (P less than .05) periods. " 10/01/1982 - "In the 1st phase of this study, tylosin was administered IM to quail, pigeons, and emus at a dosage rate of 25 mg/kg of body weight and to cranes at a dosage rate of 15 mg/kg. The average peak plasma concentrations of tylosin in quail, pigeons, cranes, and emus were 4.31, 5.63, 3.62, and 3.26 microgram/ml, respectively. " 02/01/1977 - "Data generated through 17 clinical cases indicated that the minimum inhibitory concentration for tylosin in Pasteurella spp tested was about 6.25 mcs/ml and for hemolytic Staphylococcus spp tested greater than or equal to 0.4 mug/ml. Thus, it would appear that tylosin, given at the recommended dose (6.6 to 11.0 mg tylosin activity/kg of body weight once or twice per day), would produce serum levels insufficient to treat all Pasteurella spp and some hemolytic Staphylococcus spp tested since a serum level of tylosin at slightly higher than 1 mug/ml for about 30 minutes was achieved in this study." 04/01/1981 - "Tylosin (4 mg/kg of body weight) was administered each day for 4 days, resulting in slow recovery. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Tablets
2.	Anti-Bacterial Agents (Antibiotics)
3.	Oxytetracycline (Terramycin)
4.	Chlortetracycline (Aureomycin)
5.	danofloxacin
6.	tiamulin
7.	tartaric acid (tartrate)
8.	Virginiamycin
9.	Gentamicins (Gentamicin)
10.	Lincomycin (Lincocin)

Related Therapies and Procedures

1.	Injections
2.	Drug Therapy (Chemotherapy)

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