Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer.

Abstract

OBJECTIVES:

Leucine-rich α2-glycoprotein-1 (LRG-1) is an inflammatory protein. Serum LRG-1 levels can reportedly be used as a cancer biomarker for several types of carcinoma. In the present study, we investigated the clinical usefulness of serum LRG-1 levels as a biomarker of pancreatic cancer.

METHODS:

A total of 124 patients with pancreatic cancer, 35 patients with chronic pancreatitis (CP), and 144 healthy volunteers were enrolled in the study. Serum LRG-1 levels were assayed by enzyme-linked immunosorbent assay. Immunohistochemistry was used to examine LRG-1 expression in pancreatic cancer tissues.

RESULTS:

Serum LRG-1 levels were significantly increased in patients with pancreatic cancer compared with CP patients and healthy volunteers. The LRG-1 levels increased with progressive clinical stages of pancreatic cancer. Receiver operator curve analysis showed that a combination of carbohydrate antigen 19-9 and LRG-1 resulted in a higher area under the curve for the diagnosis of pancreatic cancer. Positive staining was observed in all cases of pancreatic cancer, but positive signal was scarcely detected in tissues from CP patients or normal surrounding tissue.

CONCLUSIONS:

These results suggest that serum LRG-1 is a promising biomarker for pancreatic cancer.

• Authors: Kenta Furukawa, Koichi Kawamoto, Hidetoshi Eguchi, Masahiro Tanemura, Tsukasa Tanida, Yoshito Tomimaru, Hirofumi Akita, Naoki Hama, Hiroshi Wada, Shogo Kobayashi, Yuji Nonaka, Shinji Takamatsu, Shinichiro Shinzaki, Takashi Kumada, Shinji Satomura, Toshifumi Ito, Satoshi Serada, Tetsuji Naka, Masaki Mori, Yuichiro Doki, Eiji Miyoshi, Hiroaki Nagano
• Journal: Pancreas (Pancreas) Vol. 44 Issue 1 Pg. 93-8 (Jan 2015) ISSN: 1536-4828 [Electronic] United States
• PMID: 25058884 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Glycoproteins
• LRG1 protein, human

Topics

• Adult
• Aged
• Area Under Curve
• Biomarkers, Tumor (blood)
• Case-Control Studies
• Enzyme-Linked Immunosorbent Assay
• Female
• Glycoproteins (blood)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Neoplasm Staging
• Pancreatic Neoplasms (blood, pathology)
• Predictive Value of Tests
• ROC Curve
• Up-Regulation