Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats.

Abstract

We examined whether feeding high hydrogen generating resistant starch could suppress subacute hepatic ischemia-reperfusion injury. Rats were fed a control diet with or without 20% high amylose cornstarch (HAS) supplementation for 14 days. On day 12, rats were subject to ischemia-reperfusion treatment. Portal hydrogen concentration was higher in the HAS group compared with the control group. Increased plasma alanine and aspartate aminotransferase activities due to ischemia-reperfusion treatment tended to decrease, and a significant reduction was observed by HAS feeding when compared with the control group. In conclusion, HAS, which enhances hydrogen generation in the hindgut, alleviated subacute hepatic ischemia-reperfusion injury.

• Authors: Hiroki Tanabe, Yumi Sasaki, Tatsuro Yamamoto, Shuhachi Kiriyama, Naomichi Nishimura
• Journal: Bioscience of microbiota, food and health (Biosci Microbiota Food Health) Vol. 31 Issue 4 Pg. 103-8 ( 2012) ISSN: 2186-6953 [Print] Japan
• PMID: 24936356 (Publication Type: Journal Article)