Abstract | OBJECTIVES: The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. METHODS: RESULTS: After adjustment for traditional CVD risk factors, plasma uric acid (per s.d. of 81 μmol/l) was associated with CVD in individuals with NGM [odds ratio (OR) = 1.66, 95% CI 1.06, 2.58] but not with disturbed glucose metabolism (DGM) (OR = 0.81, 95% CI 0.55, 1.19, P interaction = 0.165). Uric acid was associated with CIMT in the total population (β = 0.024, 95% CI 0.007, 0.042) and slightly more strongly in individuals with NGM (β = 0.030, 95% CI 0.006, 0.054) than DGM (β = 0.018, 95% CI -0.009, 0.044, P interaction = 0.443). There was no association between uric acid and AAIx in any group (P interaction = 0.058). Uric acid was associated with low-grade inflammation in the total population (β = 0.074, 95% CI 0.013, 0.134, P interaction = 0.737). Adding low-grade inflammation to the models did not attenuate any of the associations. CONCLUSION: The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. A difference in the strength of the associations between individuals with NGM and DGM was suggested.
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Authors | José M A Wijnands, Annelies Boonen, Pieter C Dagnelie, Marleen M J van Greevenbroek, Carla J H van der Kallen, Isabel Ferreira, Casper G Schalkwijk, Edith J M Feskens, Coen D A Stehouwer, Sjef van der Linden, Ilja C W Arts |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 53
Issue 11
Pg. 2053-62
(Nov 2014)
ISSN: 1462-0332 [Electronic] England |
PMID | 24917566
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: [email protected]. |
Chemical References |
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Topics |
- Adult
- Atherosclerosis
(blood, epidemiology, etiology)
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, epidemiology, etiology)
- Carotid Intima-Media Thickness
- Cross-Sectional Studies
- Female
- Follow-Up Studies
- Humans
- Inflammation
(blood, complications)
- Male
- Middle Aged
- Netherlands
(epidemiology)
- Odds Ratio
- Prevalence
- Retrospective Studies
- Risk Factors
- Uric Acid
(blood)
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