Abstract | BACKGROUND: METHODS: Rats were divided into a control group, diabetic group (DM), low dose of berberine group (BerL) and high dose of berberine group (BerH). Ileum samples were analyzed using a Roche NimbleGen mRNA array, qPCR and immunohistochemistry. RESULTS: CONCLUSION: Our data suggest that berberine can improve blood glucose levels in diabetic rats. The mechanisms involved may be in the MAPK and GnRh-Glp-1 pathways in the ileum.
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Authors | Qian Zhang, Xinhua Xiao, Ming Li, Wenhui Li, Miao Yu, Huabing Zhang, Fan Ping, Zhixin Wang, Jia Zheng |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 14
Pg. 188
(Jun 09 2014)
ISSN: 1472-6882 [Electronic] England |
PMID | 24912407
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glp1r protein, rat
- Glucagon-Like Peptide-1 Receptor
- Insulin
- Plant Extracts
- Protein Precursors
- Receptors, Glucagon
- progonadoliberin I
- Berberine
- Gonadotropin-Releasing Hormone
- Glucagon-Like Peptide 1
- Glucose
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Topics |
- Animals
- Berberine
(pharmacology, therapeutic use)
- Blood Glucose
(analysis, drug effects)
- Body Weight
(drug effects)
- Carbohydrate Metabolism
(drug effects)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism)
- Diabetes Mellitus, Type 2
(drug therapy)
- Gene Expression
(drug effects)
- Glucagon-Like Peptide 1
(blood)
- Glucagon-Like Peptide-1 Receptor
- Glucose
(metabolism)
- Glucose Tolerance Test
- Gonadotropin-Releasing Hormone
(metabolism)
- Ileum
(drug effects, metabolism)
- Insulin
(blood)
- Intestinal Mucosa
(metabolism)
- Lipid Metabolism
(drug effects)
- MAP Kinase Signaling System
(drug effects)
- Male
- Phytotherapy
- Plant Extracts
(pharmacology, therapeutic use)
- Protein Precursors
(metabolism)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Receptors, Glucagon
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
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