Association of genetic polymorphisms at beta-adrenergic receptor with risk of intracerebral hemorrhagic stroke in North Indian population: a case control study.

Abstract

BACKGROUND:

Stroke is a multifactorial, polygenic disorder, influenced by both environmental and genetic factors.

AIM:

The purpose of this study was to determine the association of beta-1 and beta-2 adrenergic receptor (AR) polymorphisms with intracerebral hemorrhagic stroke (ICH) in a North Indian population.

MATERIALS AND METHODS:

One hundred and six patients with intracerebral hemorrhage (ICH) and 106 age- and sex- matched controls were recruited. Genotyping was performed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RFLP results of three samples of each genotype were confirmed by DNA sequencing.

RESULTS:

Mean age of cases and controls were 53.47 ± 14 and 52.92 ± 13.4, respectively. Significant association between Ser49Gly polymorphism of beta-1 AR and ICH in patients who had onset of disease at a later stage of life (>50 years) under a dominant model of inheritance (OR, 3.6; 95% 1.4 to 9.7) was observed. Under the dominant model of inheritance, Gln27Glu polymorphism of beta-2 AR was associated with risk of ICH (OR, 3.2; 95% CI, 1.7 to 5.8) and significant association persisted even after adjustment for demographic and other risk factor variables (OR, 2.9; 95% CI, 1.04 to 8; P = 0.04). Age-stratified analysis showed an independent significant association of Gln27Glu polymorphism of beta-2 AR with risk of ICH in patients those had onset of disease at young age (<50 years) under a dominant model of inheritance (OR, 3.5; 95% CI, 1.1 to 11).

CONCLUSION:

The present study provides the first preliminary evidence that Gln27Glu polymorphism of beta-2 AR may contribute modest effect in increase in risk of ICH in North Indian Population. Large prospective studies with large sample size are required to confirm these findings.

• Authors: Amit Kumar, Kameshwar Prasad, Manjari Tripathi, M V Padma Srivastava, S Vivekanadhan
• Journal: Neurology India (Neurol India) 2014 Mar-Apr Vol. 62 Issue 2 Pg. 183-8 ISSN: 0028-3886 [Print] India
• PMID: 24823730 (Publication Type: Journal Article)

Chemical References

• Receptors, Adrenergic, beta-1
• Receptors, Adrenergic, beta-2

Topics

• Adult
• Aged
• Base Sequence
• Case-Control Studies
• Cerebral Hemorrhage (complications, genetics)
• Female
• Humans
• India
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Receptors, Adrenergic, beta-1 (genetics)
• Receptors, Adrenergic, beta-2 (genetics)
• Risk
• Stroke (complications, genetics)