Metabolic syndrome and chronic kidney disease in an adult Korean population: results from the Korean National Health Screening.

Abstract

BACKGROUND:

This study was aimed to examine the prevalence of metabolic syndrome (MS) and chronic kidney disease (CKD), and the association between MS and its components with CKD in Korea.

METHODS:

We excluded diabetes to appreciate the real impact of MS and performed a cross-sectional study using the general health screening data of 10,253,085 (48.86 ± 13.83 years, men 56.18%) participants (age, ≥ 20 years) from the Korean National Health Screening 2011. CKD was defined as dipstick proteinuria ≥ 1 or an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2).

RESULTS:

The prevalence of CKD was 6.15% (men, 5.37%; women, 7.15%). Further, 22.25% study population had MS (abdominal obesity, 27.98%; hypertriglyceridemia, 30.09%; low high-density cholesterol levels, 19.74%; high blood pressure, 43.45%; and high fasting glucose levels, 30.44%). Multivariate-adjusted analysis indicated that proteinuria risk increased in participants with MS (odds ratio [OR] 1.884, 95% confidence interval [CI] 1.867-1.902, P<0.001). The presence of MS was associated with eGFR<60 mL/min/1.73 m(2) (OR 1.364, 95% CI 1.355-1.373, P<0.001). MS individual components were also associated with an increased CKD risk. The strength of association between MS and the development of CKD increase as the number of components increased from 1 to 5. In sub-analysis by men and women, MS and its each components were a significant determinant for CKD.

CONCLUSIONS:

MS and its individual components can predict the risk of prevalent CKD for men and women.

• Authors: Yong Un Kang, Ha Yeon Kim, Joon Seok Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
• Journal: PloS one (PLoS One) Vol. 9 Issue 5 Pg. e93795 ( 2014) ISSN: 1932-6203 [Electronic] United States
• PMID: 24807226 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Cross-Sectional Studies
• Female
• Glomerular Filtration Rate (physiology)
• Humans
• Male
• Metabolic Syndrome (epidemiology, physiopathology)
• Middle Aged
• Multivariate Analysis
• Renal Insufficiency, Chronic (epidemiology, physiopathology)
• Risk Factors