Postoperative [¹²⁵I] seed brachytherapy in the treatment of acinic cell carcinoma of the parotid gland: with associated risk factors.

Abstract

BACKGROUND:

This retrospective study was undertaken to analyze data from patients receiving iodine-125 ([(125)I]) seed brachytherapy postoperatively for the treatment of acinic cell carcinoma (ACC) of the parotid gland along with the following risk factors: residual tumor, recurrent tumor, facial nerve invasion, positive resection margins, advanced tumor stage, or tumor spillage.

PATIENTS AND METHODS:

Twenty-nine patients with ACC (17 females, 12 males; age range, 13-73 years; median age, 37.3 years) were included. Median follow-up was 58.2 months (range, 14-122 months). Patients received [(125)I] seed brachytherapy (median actuarial D90, 177 Gy) 3-41 days (median, 14 days) following surgery. Radioactivity was 18.5-33.3 MBq per seed, and the prescription dose was 80-120 Gy.

RESULTS:

The 3-, 5-, and 10-year rates of local control were 93.1, 88.7, and 88.7 %, respectively; overall survival was 96.6, 92, and 92 %; disease-free survival was 93.1, 88.4, and 88.4 %; and freedom from distant metastasis was 96.6, 91.2, and 91.2 %. Lymph node metastases were absent in all patients, although two patients died with distant metastases. Facial nerve recovery was quick, and no severe radiotherapy-related complications were noted. Recurrence history, local recurrence, and distant metastasis significantly affected overall survival.

CONCLUSION:

Postoperative [(125)I] seed brachytherapy is effective in treating ACC and has minor complications. Patients with a history of recurrence showed poor prognosis and were more likely to experience disease recurrence and develop metastases.

• Authors: Ming-Hui Mao, Jian-Guo Zhang, Jie Zhang, Lei Zheng, Shu-Ming Liu, Ming-Wei Huang, Yan Shi
• Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (Strahlenther Onkol) Vol. 190 Issue 11 Pg. 1008-14 (Oct 2014) ISSN: 1439-099X [Electronic] Germany
• PMID: 24781865 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes
• Radiopharmaceuticals

Topics

• Adolescent
• Adult
• Aged
• Brachytherapy (adverse effects, instrumentation, methods)
• Carcinoma, Acinar Cell (pathology, radiotherapy)
• Female
• Humans
• Iodine Radioisotopes (therapeutic use)
• Male
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (pathology, prevention & control)
• Parotid Neoplasms (pathology, radiotherapy)
• Postoperative Care (methods)
• Radiation Injuries (diagnosis, etiology)
• Radiopharmaceuticals (therapeutic use)
• Radiotherapy, Adjuvant (methods)
• Retrospective Studies
• Risk Factors
• Treatment Outcome
• Young Adult