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Lepidic predominant adenocarcinoma with aerogenous spread of mucin in a young patient -- a case report.

Abstract
We present a unique case of a 26 year-old female non-smoker who expired following treatment for presumed pneumonias. At autopsy, lepidic predominant adenocarcinoma with aerogenous spread of mucin without evidence of invasion, a rare diagnosis that previously would have fallen under the umbrella of "bronchioloalveolar carcinoma," was found. Histopathology showed mucin-secreting neoplastic cells lining the alveolar walls, as well as exfoliated and dense aggregates of mucinous debris filling the alveoli. The immediate cause of death was respiratory failure, most likely due to the significant amount of tumor-produced mucin that filled the alveolar spaces, which literally drowned the patient.
AuthorsElise Nguyen, Matthew Hakimi, Bahman Chavoshan, William Stringer, Samuel W French
JournalExperimental and molecular pathology (Exp Mol Pathol) Vol. 96 Issue 3 Pg. 400-4 (Jun 2014) ISSN: 1096-0945 [Electronic] Netherlands
PMID24768586 (Publication Type: Case Reports, Journal Article)
CopyrightPublished by Elsevier Inc.
Chemical References
  • Mucins
Topics
  • Adenocarcinoma, Bronchiolo-Alveolar (diagnosis, pathology)
  • Adult
  • Fatal Outcome
  • Female
  • Humans
  • Lung (pathology)
  • Lung Neoplasms (diagnosis, pathology)
  • Mucins (genetics, metabolism)

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