Haptoglobin genotype and risk of diabetic nephropathy in patients with type 1 diabetes mellitus: a study on a Spanish population.

Abstract

BACKGROUND:

Few reports have studied the possible association between the haptoglobin (Hp) genotype and the risk of diabetic nephropathy (DN) in type 1 diabetes (T1D), with conflicting results to date.

AIMS:

To study whether the 2-2 Hp genotype is associated with an increased risk of overt DN in a Spanish population with T1D.

METHODS:

We performed a case-control study in a Spanish population.

CASES:

T1D patients with end-stage renal disease (stage 5 of NKF-KDOQI), awaiting reno-pancreatic transplantation or having already been transplanted (reno-pancreatic or renal alone).

CONTROLS:

T1D patients, matched for sex and time of diabetes evolution, with preserved renal function and normal urinary albumin excretion. Hp genotyping was done using polymerase chain reaction and electrophoresis.

RESULTS:

We included 57 cases and 57 controls in the study. There were no statistically significant differences in gender (70% vs. 61% males, p=1.0) or the duration of diabetes (23.0 ± 6.7 vs. 20.8 ± 9.3 years; p=0.1), although the age of onset of diabetes was lower in the cases (14.1 ± 6.8 vs. 17.7 ± 10.1 years, p=0.03). The frequency of genotypes 1-1, 1-2 and 2-2 was 19.3%, 42.1% and 38.6% in cases and 17.5%, 49.1% and 33.4% in controls, respectively, with no statistically significant differences between groups (p=0.8). Conditional logistic regression analysis showed no significant association between genotype 2-2 of Hp and the development of DN (OR 1.14, CI 0.52-2.52).

CONCLUSIONS:

In our sample of a Spanish population with T1D, no association was found between the Hp genotype and risk of overt DN.

• Authors: Antonio J Amor, Silvia Canivell, Josep Oriola, Maria J Ricart, Ana M de Hollanda, Anna Bosch-Comas, Enric Esmatjes
• Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia (Nefrologia) Vol. 34 Issue 2 Pg. 212-5 ( 2014) ISSN: 1989-2284 [Electronic] Spain
• PMID: 24658196 (Publication Type: Journal Article)

Chemical References

• HP protein, human
• Haptoglobins

Topics

• Case-Control Studies
• Diabetes Mellitus, Type 1 (complications)
• Diabetic Nephropathies (epidemiology, genetics)
• Female
• Genotype
• Haptoglobins (genetics)
• Humans
• Male
• Risk
• Spain