BK virus-associated urothelial carcinoma of a ureter graft in a renal transplant recipient: a case report.

Abstract

BACKGROUND:

Urothelial carcinomas of ureter grafts in renal transplant patients are rare. Here we report our experience with a case of BK virus-associated urothelial carcinoma in a ureter graft.

CASE REPORT:

A 47-year-old man developed chronic renal failure secondary to diabetes mellitus and started maintenance hemodialysis in September 2007. Two months later, the patient received a renal transplant from his 70-year-old mother. The patient developed BK virus-associated nephropathy 1 year after transplantation and presented with a decline in renal function and hydronephrosis in the transplanted kidney 4 years 6 months after transplantation. Cystoscopy and retrograde pyelography revealed an irregular filling defect in the ureter graft. Cytologic diagnosis of his urine revealed a high-grade urothelial carcinoma. Computerized tomography showed a cT2 ureteral tumor and no involvement of other organs. The patient subsequently underwent a transplant nephroureterectomy with bladder cuff resection. Histopathologic findings revealed a high-grade urothelial carcinoma, pT2, in the ureter graft with SV40-positive staining. The patient was closely observed without adjuvant chemotherapy therapy and remained disease free 1 year after surgery. Renal transplant recipients with BK virus infection are at high risk of developing urologic malignancies. Close attention is necessary to diagnose post-transplantation urologica malignancies as early as possible.

• Authors: M Oikawa, S Hatakeyama, T Fujita, R Murakami, K Hagiwara, T Narita, D Noro, T Tanaka, Y Tanaka, Y Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Y Hashimoto, T Koie, S Narumi, C Ohyama
• Journal: Transplantation proceedings (Transplant Proc) Vol. 46 Issue 2 Pg. 616-9 ( 2014) ISSN: 1873-2623 [Electronic] United States
• PMID: 24656027 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Topics

• BK Virus (pathogenicity)
• Humans
• Kidney Transplantation (adverse effects)
• Male
• Middle Aged
• Ureter (surgery)
• Urinary Bladder Neoplasms (etiology, virology)
• Urography