Abstract | WHAT IS KNOWN AND OBJECTIVE:
Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous. We describe a retired nurse with history of depression, who began to develop drug-seeking behaviour after her first receiving of an intramuscular (IM) DPH injection due to urticaria. CASE SUMMARY: The 49-year-old patient had developed IM DPH dependence within 4 months. She needed to receive psychiatric inpatient treatment because of depressive mood, serious myonecrosis over injected sites, and prolongation of QT interval. WHAT IS NEW AND CONCLUSION:
|
Authors | T-Y Chen, Y-W Yeh, S-C Kuo, C-Y Chen, T-P Lin, C-C Chang |
Journal | Journal of clinical pharmacy and therapeutics
(J Clin Pharm Ther)
Vol. 39
Issue 3
Pg. 325-7
(Jun 2014)
ISSN: 1365-2710 [Electronic] England |
PMID | 24597640
(Publication Type: Case Reports, Journal Article)
|
Copyright | © 2014 John Wiley & Sons Ltd. |
Chemical References |
- Histamine H1 Antagonists
- Diphenhydramine
|
Topics |
- Arrhythmias, Cardiac
(chemically induced)
- Brugada Syndrome
- Cardiac Conduction System Disease
- Depression
(epidemiology)
- Diphenhydramine
(administration & dosage, adverse effects)
- Drug-Seeking Behavior
- Female
- Heart Conduction System
(abnormalities)
- Histamine H1 Antagonists
(administration & dosage, adverse effects)
- Humans
- Injections, Intramuscular
- Middle Aged
- Muscles
(pathology)
- Necrosis
- Substance-Related Disorders
(epidemiology)
|