Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes.

Abstract

Cardiac hypertrophy is an independent risk factor for cardiovascular disease and its subsequent progression to heart failure represents a major cause of morbidity and mortality in the world. CGA is an important component of Chinese herbal medicine, acting as an antioxidant, scavenging free radicals and preventing inflammation. This study found that with the pre-treatment of chlorogenic acid in Iso-induced neonatal rat myocytes, the levels of the hypertrophic markers, ANP, BNP and β-MHC decreased. The nuclear translocation of NF-κB was blocked, whereas NF-κBIA, an inhibitor of NF-κB, was upregulated accordingly. And the level of the intracellular ROS was also reduced. These data reveal that chlorogenic acid may inhibit Iso-induced cardiac hypertrophy by attenuating NF-κB signaling pathway and suppressing ROS.

• Authors: Yanfei Li, Dan Shen, Xiaomei Tang, Xin Li, Da Wo, Hongwei Yan, Rui Song, Jian Feng, Ping Li, Jie Zhang, Jue Li
• Journal: Toxicology letters (Toxicol Lett) Vol. 226 Issue 3 Pg. 257-63 (May 02 2014) ISSN: 1879-3169 [Electronic] Netherlands
• PMID: 24583048 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• NF-kappa B
• Reactive Oxygen Species
• Chlorogenic Acid
• Isoproterenol

Topics

• Animals
• Animals, Newborn
• Cardiomegaly (chemically induced, prevention & control)
• Cells, Cultured
• Chlorogenic Acid (pharmacology)
• Isoproterenol (pharmacology)
• Myocytes, Cardiac (metabolism, pathology)
• NF-kappa B (physiology)
• Protein Transport (drug effects)
• Rats
• Rats, Sprague-Dawley
• Reactive Oxygen Species (metabolism)
• Signal Transduction (drug effects)