Abstract | BACKGROUND: OBJECTIVE: The chemical structures and names of bath salts identified by the Ohio Attorney General's Bureau of Criminal Investigation are presented. Based on their common pharmacophores, we review the history, pharmacology, toxicology, detection methods, and clinical implications of synthetic cathinones. Through the integration of this information, the pharmacological basis for the management of patients using synthetic cathinones is presented. DISCUSSION:
Synthetic cathinones activate central serotonergic and dopaminergic systems contributing to acute psychosis and the peripheral activation of the sympathetic nervous system. The overstimulation of the sympathetic nervous system contributes to the many toxicities reported with bath salt use. The pharmacological basis for managing these patients is targeted at attenuating the activation of these systems. CONCLUSIONS:
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Authors | Matthew L Banks, Travis J Worst, Daniel E Rusyniak, Jon E Sprague |
Journal | The Journal of emergency medicine
(J Emerg Med)
Vol. 46
Issue 5
Pg. 632-42
(May 2014)
ISSN: 0736-4679 [Print] United States |
PMID | 24565885
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Alkaloids
- Central Nervous System Stimulants
- Designer Drugs
- Psychotropic Drugs
- cathinone
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Topics |
- Alkaloids
(adverse effects, chemistry)
- Central Nervous System Stimulants
(adverse effects, chemistry)
- Designer Drugs
(adverse effects, chemistry)
- Humans
- Psychotropic Drugs
(adverse effects)
- Substance-Related Disorders
(diagnosis, therapy)
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