Abstract | BACKGROUND: Psychiatric patients appear to be at lower risk of cancer. Some antipsychotic drugs might have inhibitory effects on tumor growth, including penfluridol, a strong agent. To test this, we conducted a study to determine whether penfluridol exerts cytotoxic effects on tumor cells and, if so, to explore its anti- tumor mechanisms. METHODS: RESULTS:
Penfluridol inhibited the proliferation of B16 melanoma (B16/ F10), LL/2 lung carcinoma (LL/2), CT26 colon carcinoma (CT26) and 4T1 breast cancer (4T1) cells in vitro. In vivo penfluridol was particularly effective at inhibiting LL/2 lung tumor growth, and obviously prolonged the survival time of mice bearing LL/2 lung tumors implanted subcutaneously. Accumulated unesterified cholesterol was found in all of the cancer cells treated with penfluridol, and this effect was most evident in LL/2, 4T1 and CT26 cells. No significant difference in serum cholesterol levels was found between the normal saline-treated mice and the penfluridol-treated mice. However, a dose-dependent decrease of total cholesterol in tumor tissues was observed in penfluridol-treated mice, which was most evident in B16/F10-, LL/2-, and 4T1-tumor-bearing mice. CONCLUSION:
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Authors | Lu Wu, Yan-Yang Liu, Zhi-Xi Li, Qian Zhao, Xia Wang, Yang Yu, Yu-Yi Wang, Yi-Qin Wang, Feng Luo |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 15
Issue 1
Pg. 489-94
( 2014)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 24528079
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Penfluridol
- Cholesterol
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Topics |
- Animals
- Antipsychotic Agents
(pharmacology, therapeutic use)
- Breast Neoplasms
(drug therapy, metabolism)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cholesterol
(blood, metabolism)
- Colonic Neoplasms
(drug therapy, metabolism)
- Female
- Homeostasis
(drug effects)
- Lung Neoplasms
(drug therapy, metabolism)
- Melanoma, Experimental
(drug therapy, metabolism)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Penfluridol
(pharmacology, therapeutic use)
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