Abstract | AIMS: METHODS AND RESULTS: Soluble urokinase plasminogen activator receptor was measured in 4530 subjects (aged 46–68 years, 61% women), who participated in the Malmö Diet and Cancer study during 1991–1996. Incident cases of HF and AF were identified from the Swedish hospital discharge register during a median follow-up of 16.3 years. During follow-up, 109 subjects (55% men) were diagnosed with new-onset HF and 321 individuals (50% men) with AF. suPAR was significantly associated with increased plasma levels of NT-proBNP (P<0.001). suPAR was significantly associated with incidence of HF [hazard ratio (HR) for the third vs. first tertile 3.33, 95% confidence interval (CI) 1.91–5.81 after adjustment for age and sex; and HR 1.82, 95% CI 1.02–3.27, P for trend 0.018 after adjustment for conventional risk factors and biomarkers]. suPAR was significantly associated with incidence of AF, when adjusted for age and sex (HR 1.40, 95% CI 1.06–1.85). However, this relationship was non-significant after adjustment for conventional risk factors and biomarkers. CONCLUSION:
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Authors | Yan Borné, Margaretha Persson, Olle Melander, J Gustav Smith, Gunnar Engström |
Journal | European journal of heart failure
(Eur J Heart Fail)
Vol. 16
Issue 4
Pg. 377-83
(Apr 2014)
ISSN: 1879-0844 [Electronic] England |
PMID | 24464777
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 The Authors. European Journal of Heart Failure © 2014 European Society of Cardiology. |
Chemical References |
- Biomarkers
- Peptide Fragments
- Receptors, Urokinase Plasminogen Activator
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
- C-Reactive Protein
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Topics |
- Aged
- Atrial Fibrillation
(blood, epidemiology)
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Heart Failure
(blood, epidemiology)
- Humans
- Incidence
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Receptors, Urokinase Plasminogen Activator
(blood)
- Risk Factors
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