Effects of antioxidant drugs in rats with acute renal injury.

Abstract

Acute renal failure is mainly caused by ischemia/reperfusion (I/R) injury or nephrotoxic drugs, in which reactive oxygen species (ROS) may play an important role. Therefore, antioxidants are expected to decrease the vulnerability of renal injury associated with oxidative challenges. α-Lipoic acid (α-LA), potent antioxidant, could act as ROS scavengers, iron chelators and enzyme modulators. In rats with acute renal injury, dysregulation of aquaporin (AQP) water channels and sodium transporters has been noted. I/R injury or cisplatin induced marked down-regulation of AQP1, AQP2 and AQP3 water channels, and type-3 Na-H exchanger, Na,K-ATPase, and Na-K-2Cl cotransporters, in association with impairment of urinary concentration and tubular sodium reabsorption. Treatment with α-LA prevented the dysregulation of AQP channels and sodium transporters, along with improved urinary concentrating capability and renal sodium reabsorption.

• Authors: Eun Hui Bae, Jongun Lee, Soo Wan Kim
• Journal: Electrolyte & blood pressure : E & BP (Electrolyte Blood Press) Vol. 5 Issue 1 Pg. 23-7 (Jun 2007) ISSN: 1738-5997 [Print] Korea (South)
• PMID: 24459496 (Publication Type: Journal Article, Review)