Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model.

Abstract

The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.

• Authors: Goeun Yang, Dongsun Park, Sun Hee Lee, Dae-Kwon Bae, Yun-Hui Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Jin Tae Hong, Heon-Sang Jeong, Hee Jung Kim, Su Kil Jang, Seong Soo Joo, Yun-Bae Kim
• Journal: Biomolecules & therapeutics (Biomol Ther (Seoul)) Vol. 21 Issue 6 Pg. 454-61 (Nov 2013) ISSN: 1976-9148 [Print] Korea (South)
• PMID: 24404336 (Publication Type: Journal Article)