Introduction. The objective of this study was to clarify how
pitavastatin affects
glucose and lipid metabolism, renal function, and oxidative stress. Methods. Ten Japanese men (average age of 33.9 years) were orally administered 2 mg of
pitavastatin for 4 weeks. Postprandial
glucose,
lipoprotein metabolism, and oxidative stress markers were evaluated at 0 and 4 weeks of
pitavastatin treatment (2 mg once daily) with a test meal consisting of total calories: 460 kcal,
carbohydrates: 56.5 g (226 kcal),
protein: 18 g (72 kcal),
lipids: 18 g (162 kcal), and NaCl: 1.6 g. Metabolic parameters were measured at 0, 60, and 120 minutes after test meal ingestion. Results. After administration of
pitavastatin, serum total
cholesterol,
low-density lipoprotein cholesterol,
apolipoprotein B,
arachidonic acid,
insulin, and adjusted urinary excretion of
uric acid decreased, whereas
creatinine clearance (C Cr) and
uric acid clearance (C UA) increased. And postprandial versus fasting urine
8-hydroxydeoxyguanosine remained unchanged, while postprandial versus fasting
isoprostane decreased after
pitavastatin treatment. Next, we compared postprandial
glucose and lipid metabolism after test meal ingestion before and after
pitavastatin administration. Incremental areas under the curve significantly decreased for
triglycerides (P < 0.05) and
remnant-like particle cholesterol (P < 0.01), while those for
apolipoprotein E (
apoE),
glucose,
insulin, and
high-sensitivity C-reactive protein remained unchanged. Conclusion.
Pitavastatin improves postprandial oxidative stress along with
hyperlipidemia.