Abstract | BACKGROUND: METHODS: The effect of galectins-2, -4 and -8, whose circulating levels are highly increased in cancer patients, on endothelial secretion of cytokines was assessed in vitro by cytokine array and in mice. The relationship between serum levels of galectins and cytokines was analysed in colon and breast cancer patients. RESULTS: Galectins-2, -4 and -8 at pathological concentrations induce secretion of G-CSF, IL-6, MCP-1 and GROα from the blood vascular endothelial cells in vitro and in mice. Multiple regression analysis indicates that increased circulation of these galectins accounts for 41∼83% of the variance of these cytokines in the sera of colon and breast cancer patients. The galectin-induced secretion of these cytokines/ chemokines is shown to enhance the expression of endothelial cell surface adhesion molecules, causing increased cancer-endothelial adhesion and increased endothelial tubule formation. CONCLUSION: The increased circulation of galectins -2, -4 and -8 in cancer patients contributes substantially to the increased circulation of G-CSF, IL-6 and MCP-1 by interaction with the blood vascular endothelium. These cytokines and chemokines in turn enhance endothelial cell activities in angiogenesis and metastasis.
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Authors | C Chen, C A Duckworth, B Fu, D M Pritchard, J M Rhodes, L-G Yu |
Journal | British journal of cancer
(Br J Cancer)
Vol. 110
Issue 3
Pg. 741-52
(Feb 04 2014)
ISSN: 1532-1827 [Electronic] England |
PMID | 24384681
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCL2 protein, human
- CXCL1 protein, human
- Chemokine CCL2
- Chemokine CXCL1
- Galectin 2
- Galectin 4
- Galectins
- Interleukin-6
- LGALS8 protein, human
- Granulocyte Colony-Stimulating Factor
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Topics |
- Animals
- Chemokine CCL2
(metabolism)
- Chemokine CXCL1
(metabolism)
- Galectin 2
(blood)
- Galectin 4
(blood)
- Galectins
(blood)
- Granulocyte Colony-Stimulating Factor
(metabolism)
- Humans
- Interleukin-6
(genetics)
- Mice
- Neoplasm Metastasis
(pathology)
- Neoplasms
(blood, genetics)
- Neoplastic Cells, Circulating
- Neovascularization, Pathologic
(blood, genetics)
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