Lipid hydroperoxide-derived modification of proteins in gastrointestinal tract.

Abstract

Role of lipid peroxidation in the pathogenesis of gastrointestinal diseases has been evaluated by measuring the tissue levels of lipid peroxides as thiobarbituric acid-reactive substances in the animal models as well as human. Recently, N (ε)-(hexanoyl)lysine (HEL) and 4-hydroxy-2-nonenal (HNE) are recognized as reliable and sensitive biomarkers for the early phase and the late phase of lipid peroxidation, respectively. The presence of HNE- and HEL-modified proteins has been demonstrated in in vivo models of several gastrointestinal diseases. In the present review, we introduced HNE-modification of TRPV1 channel in esophageal epithelial cells, HEL-modification of tropomyosin 1 (TMP1) in gastric cancer cells, and HEL-modification of gastrokine 1 in the healing of gastric ulcer.

• Authors: Yuji Naito, Tomohisa Takagi, Osamu Handa, Toshikazu Yoshikawa
• Journal: Sub-cellular biochemistry (Subcell Biochem) Vol. 77 Pg. 137-48 ( 2014) ISSN: 0306-0225 [Print] United States
• PMID: 24374925 (Publication Type: Journal Article, Review)

Chemical References

• Aldehydes
• Biomarkers
• Hexanols
• Lipid Peroxides
• Proteins
• 4-hydroxy-2-nonenal
• Lysine

Topics

• Aldehydes (chemistry, metabolism)
• Biomarkers
• Gastrointestinal Tract (metabolism, pathology)
• Hexanols (chemistry, metabolism)
• Humans
• Lipid Peroxidation
• Lipid Peroxides (chemistry, metabolism)
• Lysine (metabolism)
• Oxidative Stress
• Proteins (chemistry, metabolism)