Adipose tissue trans-fatty acids and changes in body weight and waist circumference.

Abstract

Previous studies have suggested that the intake of trans-fatty acids (TFA) plays a role in the development of obesity. The proportions of adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the use of these biomarkers may provide a more accurate measure of habitual TFA intake than that obtained with dietary questionnaires. The objective of the present study was to investigate the associations between the proportions of specific TFA in adipose tissue and subsequent changes in weight and waist circumference (WC). The relative content of fatty acids in adipose tissue biopsies from a random sample of 996 men and women aged 50-64 years drawn from a Danish cohort study was determined by GC. Baseline data on weight, WC and potential confounders were available together with information on weight and WC 5 years after enrolment. The exposure measures were total trans-octadecenoic acids (18:1t), 18:1 Δ6-10t, vaccenic acid (18:1 Δ11t) and rumenic acid (18:2 Δ9c, 11t). Data were analysed using multiple regression with cubic spline modelling. The median proportion of total adipose tissue 18:1t was 1.52% (90% central range 0.98, 2.19) in men and 1.47% (1.01, 2.19) in women. No significant associations were observed between the proportions of total 18:1t, 18:1 Δ6-10t, vaccenic acid or rumenic acid and changes in weight or WC. The present study suggests that the proportions of specific TFA in adipose tissue are not associated with subsequent changes in weight or WC within the exposure range observed in this population.

• Authors: Camilla P Hansen, Tina L Berentzen, Jane N Østergaard, Christina C Dahm, Lars I Hellgren, Erik B Schmidt, Anne Tjønneland, Thorkild I A Sørensen, Kim Overvad, Marianne U Jakobsen
• Journal: The British journal of nutrition (Br J Nutr) Vol. 111 Issue 7 Pg. 1283-91 (Apr 14 2014) ISSN: 1475-2662 [Electronic] England
• PMID: 24286469 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Dietary Fats
• Linoleic Acids, Conjugated
• Oleic Acids
• Trans Fatty Acids
• 9,11-linoleic acid
• 11-octadecenoic acid

Topics

• Adipose Tissue, White (metabolism)
• Biomarkers (metabolism)
• Biopsy, Needle
• Cohort Studies
• Denmark
• Dietary Fats (adverse effects, metabolism)
• Female
• Follow-Up Studies
• Humans
• Linoleic Acids, Conjugated (adverse effects, metabolism)
• Lost to Follow-Up
• Male
• Middle Aged
• Obesity (etiology, metabolism, pathology)
• Oleic Acids (adverse effects, metabolism)
• Registries
• Surveys and Questionnaires
• Trans Fatty Acids (adverse effects, metabolism)
• Waist Circumference
• Weight Gain