Abstract | BACKGROUND/PURPOSE:
Huai Qi Huang (HQH) is a compound Chinese herbal medicine that contains Trametes robiniophila murr, wolfberry fruit, and Polygonatum. In the present study, we investigated the effects of HQH on patients with mild immunoglobulin A nephropathy (IgAN) through a prospective randomized controlled study. METHODS: Forty-five adults diagnosed with IgAN according to renal pathology, who had hematuria or/and proteinuria (≤ 2 g/day), were randomly assigned to receive HQH or no treatment for 12 weeks. Twenty-four hour urinary protein excretion and hematuria were measured at Weeks 0, 4, 8, and 12. The rate of complete remission of proteinuria and hematuria was evaluated. Any adverse events induced by HQH were also observed during the treatment period. RESULTS: Twenty-four hour urinary protein excretion was significantly reduced by HQH treatment compared with that in the control group at Weeks 8 and 12. A much higher rate of complete remission of proteinuria was observed in the HQH group than in control group at Week 12. HQH administration also obviously reduced the extent of hematuria compared with that in the control group at Week 12. HQH treatment dramatically increased the rate of complete remission of hematuria compared with that in control group at Weeks 8 and 12. No obvious adverse events caused by HQH were observed. CONCLUSION:
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Authors | Lei-Ting Li, Ming-Yang Shi, Shi-Yao Wei, Tong Li, Bing Li |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 112
Issue 12
Pg. 766-72
(Dec 2013)
ISSN: 0929-6646 [Print] Singapore |
PMID | 24280442
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013. Published by Elsevier B.V. |
Chemical References |
- Drugs, Chinese Herbal
- huai qi huang
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Topics |
- Adult
- Drugs, Chinese Herbal
(adverse effects, therapeutic use)
- Female
- Glomerulonephritis, IGA
(complications, drug therapy)
- Hematuria
(drug therapy, etiology)
- Humans
- Lycium
- Male
- Phytotherapy
- Polygonatum
- Prospective Studies
- Proteinuria
(drug therapy, etiology)
- Trametes
- Young Adult
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