[Chemical constituents of chloroform fraction from leaves of Chimonanthus salicifolius].

Abstract

To explore anti-tumor active components of Chimonanthus salicifolius, the phytochemistry of the chloroform fraction from leaves extract was investigated by repeated silica gel column chromatography. Twelve compounds were isolated and their structures were identified by physicochemical properties and spectroscopic data analysis as 9-epi-blumenol C(1), blumenol C(2), (+)-dehydrovomifoliol (3), (+)-vomifoliol (4), robinlin (5), (-)-loliolide (6), isofraxidin (7), scopoletin (8), 6,7-dimethoxycoumarin (9), 6, 7, 8-trimethoxycoumarin (10), beta-sitostenone (11), and beta-stigmasterol(12). Compounds 1-6 belonging to nor-sesquiterpenoids were isolated from the family Calycanthaceae for the first time. Compound 1 was a new natural product. Compounds 7, 11 and 12 were obtained from this plant for the first time.

• Authors: Yao Zhang, Jin-Wei Hua, Xiu-Yan Wang, Wen-Liang Cheng, Hou-Xing Lei, Ke-Jun Cheng, Pei-Zhong Yu
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 38 Issue 16 Pg. 2661-4 (Aug 2013) ISSN: 1001-5302 [Print] China
• PMID: 24228583 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Drugs, Chinese Herbal
• Chloroform

Topics

• Antineoplastic Agents (analysis, isolation & purification)
• Calycanthaceae (chemistry)
• Chloroform (chemistry)
• Drugs, Chinese Herbal (analysis, isolation & purification)
• Plant Leaves (chemistry)