Chloroform (Trichloromethane)

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693 relevant articles (32 outcomes, 37 trials/studies) found for this Bio-Agent

Description: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.

Also Known As:

Trichloromethane; Methane, trichloro-

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	England, Marilyn J: 2 articles (10/2008 - 06/2002)
2.	Waag, David M: 2 articles (10/2008 - 06/2002)
3.	Manivannan, B: 2 articles (03/2002 - 07/2000)
4.	Pathak, N: 2 articles (03/2002 - 07/2000)
5.	Lohiya, N K: 2 articles (03/2002 - 07/2000)
6.	Mishra, P K: 2 articles (03/2002 - 07/2000)
7.	Bolt, Christopher R: 1 article (10/2008)
8.	Williams, Jim C: 1 article (10/2008)
9.	Clewell, Harvey J: 1 article (12/2007)
10.	Andersen, Melvin E: 1 article (12/2007)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 01/01/1981 - "In mice, 31 compounds produced some protection against chloroform-induced tachyarrhythmias at subcutaneous doses of 100 mg/kg, and 6 compounds produced no detectable toxicity at doses protecting 80% or more of the animals. " 09/01/1981 - "The target compounds were evaluated in mice for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity. " 07/01/1981 - "The target compounds were evaluated in mice both for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity. " 07/01/1984 - "Antiarrhythmic activity was determined as protection against chloroform-induced ventricular arrhythmias and beta blockade as inhibition of isoproterenol-induced tachycardia. " 02/01/2001 - "Experimental study showed that YFOL could reduce the chloroform induced ventricular fibrillation occurrence in mice, delay the initiating time of ventricular extrasystole, tachycardia and fibrillation induced by aconitine, BaCl2 and coronary artery ligation in rats, or shorten the lasting time of arrhythmia, reduce the attacking rate of ventricular extrasystole. " Order ALL the reference details at left...
2.	Body Weight (Weight, Body) 01/01/2009 - "Taken together, the results demonstrate that while chloroform administered via the drinking water affects body weight and selected hematological parameters at high dose levels, overall immune responses, as measured in several tests for immune function, are not compromised." 01/01/2009 - "Some significant changes were also observed for body weights, water consumption, and organ weights; however, most of these effects were only observed at the highest treatment level of chloroform (250 ppm). " 09/01/2007 - "Doses of the chloroform extract (CEEI) ranging from 12.5-100 mg/kg body weight, significantly (p < 0.05) stimulated the humoral and cell-mediated immune responses in a dose-dependent manner. " 04/01/2007 - "At autopsy on Day 10 postcoitum, 7-25% loss in body weight was recorded at the minimum effective contraceptive dose (MED) in rats treated with the ethanolic extract as well as its chloroform-soluble fraction on Days 1-7, 1-5 and 1 postcoitum, in comparison with the 6-7% increase in body weight observed in vehicle control rats. " 09/01/2006 - "The variability in exposure conditions (e.g., shower duration) was shown to contribute more than the variability in pharmacokinetics (e.g., body weight) to the predicted variability in blood and exhaled breath concentrations of chloroform. " Order ALL the reference details at left...
3.	Ventricular Fibrillation 03/01/1991 - "The incidence of ventricular fibrillation of mice induced by chloroform were reduced from 100% to 20% and 10% by i.v. Ani 1 and 10 mg.kg-1 respectively. " 01/01/1981 - "Antiarrhythmic activity was measured as decreased ventricular vulnerability to electrical fibrillation in the dog and prevention of chloroform-induced ventricular fibrillation in the mouse. " 10/01/1979 - "All compounds were evaluated for their ability to protect mice against chloroform-induced ventricular fibrillation. " 09/01/1979 - "These compounds were initially evaluated in mice for acute toxicity and for their ability to protect against chloroform-induced ventricular fibrillation. " 01/01/1979 - "COP showed also a definite antagonizing activity against chloroform-induced ventricular fibrillation in mice." Order ALL the reference details at left...
4.	DNA Damage 07/01/1995 - "With the SOS chromotest, all the chemicals studied except chloroform were found to induce primary DNA damage in Escherichia coli PQ37. " 01/01/2006 - "Taken together, these results suggest that although both tested compounds (chloroform and eucalyptol) are strong cytotoxicants, it seems that they are not likely to increase the level of DNA damage on mammalian cells." 05/01/2007 - "OBJECTIVES: Taking into consideration that DNA damage and cellular death play important roles during carcinogenesis, the purpose of the present study was to evaluate in vitro genotoxic or cytotoxic effects of chloroform and eucalyptol by single cell gel (comet) assay and trypan blue exclusion test, respectively. " 08/12/2009 - "Although we found low in vitro free radical scavenging activity for the benzene insoluble fraction from EAF (EBSF), the chloroform soluble fraction from EAF (ECSF), the chloroform soluble fraction from MF (MCSF), and the ethyl acetate soluble fraction from MF (MESF), these fractions showed no effect on H2O2-induced lipid peroxidation and pBR322 DNA damage. " 01/01/2002 - "The comet assay showed that acetone extract (100 microg/mL) was more effective in reducing the DNA damage caused by 4-NQO (ca. 90%), whereas the chloroform, ethyl acetate, and diethyl ether extracts were cytotoxic. " Order ALL the reference details at left...
5.	Inflammation 01/01/2007 - "Among the tested fractions, chloroform fraction of garlic seems to be very potent in attenuating the free radical generation from rat neutrophils, which could be beneficial in the inflammation associated pathological conditions." 05/01/1991 - "A methanolic fraction of a chloroform extract of defatted Pluchea indica roots was investigated for its antiinflammatory potential against several models of inflammation. " 01/01/1996 - "These results indicate that repeated topical chloroform treatment of the rat skin induces neurogenic vascular inflammation accompanied by an increase in mast cell response." 01/01/1996 - "The effects of mild inflammation induced by topical chloroform treatment on plasma extravasation and mast cell response were studied in normal innervated and denervated rat skin. " 10/01/1997 - "The following points summarize the critical data: (1) a substantial body of data demonstrates a lack of direct in vivo or in vitro genotoxicity of chloroform; (2) chloroform induces liver and kidney tumors in long-term rodent cancer bioassays only at doses that induce frank toxicity at these target sites; (3) the chloroform doses required to produce tumors in susceptible species exceed the MTD, often by a considerable margin; (4) cytotoxicity and compensatory cell proliferation are associated with the chloroform doses required to induce liver or kidney tumors in susceptible rodent species; (5) there are no instances of chloroform-induced tumors that are not preceded by this pattern of dose-dependent toxic responses; (6) it is biologically plausible that cytolethality leads to chronically stimulated cell proliferation and related events such as inflammation and growth stimulation which act to initiate and promote the carcinogenic process; and (7) the consistently linked cellular events of cytolethality and subsequent cell proliferation, for which doses of no adverse effect have been clearly shown to exist, are one of the biological prerequisites for chloroform-induced tumors in animals. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Methanol (Carbinol)
2.	ethyl acetate
3.	Ethyl Ether (Ether)
4.	Acetone
5.	Acetaminophen (Paracetamol)
6.	Ethanol (Ethyl Alcohol)
7.	Corn Oil (Oil, Corn)
8.	Aconitine
9.	1-Butanol (n Butanol)
10.	Carrageenan

Related Therapies and Procedures

1.	Oral Administration
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Splenectomy
5.	Self Medication

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