scoparone

05/01/2020 - "In LPS-induced macrophages, scoparone regulates autophagy and further suppresses inflammation by inhibiting the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway and enhancing autophagic flux. "
01/01/2018 - "Scoparone suppressed the leakage of blood brain barrier, inflammation and apoptosis. "
01/01/2018 - "In our present study, we attempted to investigate if scoparone could attenuate seizures-induced blood brain barrier breakdown, inflammation and apoptosis. "
05/01/2020 - "Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages."
10/01/2019 - "We found that scoparone can effectively improve hepatic steatosis, apoptosis, inflammation, and fibrosis in an MCD diet-induced NASH murine model. "

06/01/2018 - "These findings suggest that scoparone may be used a novel therapeutic agent against cardiac fibrosis."
10/08/2020 - "The aim of this study was to investigate the role of scoparone (SCO) in hepatic fibrosis. "
06/01/2018 - "However, there are no studies focusing on the effects of scoparone against cardiac fibrosis. "
01/01/2016 - "This study was to investigate the influence of scoparone on pancreatic fibrosis in vitro and in vivo. "
10/08/2020 - "Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway."

01/01/2013 - "This study was undertaken to investigate the anti-tumor activity of scoparone against DU145 prostate cancer cells and to determine whether its effects are mediated by inhibition of STAT3 activity. "
09/15/2021 - "The in vivo effect of scoparone on pancreatic cancer cell proliferation was detected using a xenograft tumor model in nude mice as well as immunohistochemistry. "
01/01/2013 - "Our findings suggest that scoparone elicits an anti-tumor effect against DU145 prostate cancer cells in part through inhibition of STAT3 activity. "
01/01/2013 - "Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity."
09/15/2021 - "Moreover, compared with the control group, xenograft tumors, in the 200 μmol/L scoparone treatment group, were smaller in volume and lighter in weight, and the percentages of Ki65- and PCNA-positive cells were decreased. "

11/01/2014 - "Mice model of acute lung injury (ALI), induced by intranasal instillation of LPS, was used to investigate the protective effects of scoparone in vivo. "
11/01/2014 - "The purpose of this study was to investigate the protective effects and molecular mechanisms of scoparone on lipopolysaccharide (LPS)-induced acute lung injury in mice. "
11/01/2014 - "Protective effects of scoparone against lipopolysaccharide-induced acute lung injury."

07/01/2013 - "The purpose of this study was to investigate the protective effects and molecular mechanisms of scoparone on d-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure (FHF) in mice. "
07/01/2013 - "Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice."