[Cardioprotective properties of zoniporide studied on experimental ischemia and reperfusion models in rat myocardium].

Abstract

Using the experimental model of rat heart ischemia/reperfusion, it is established that zoniporide (inhibitor of Na+/H+ exchanger) produces a significant (1.4-fold) decrease in the area of myocardial necrosis, 2.1-fold decrease in the serum troponin I level, and 2-fold decrease in the severity of post-reperfusion arrhythmias.

• Authors: N A Gurova, A A Spasov, A S Timofeeva, A A Zheltova, V Iu Fedorchuk
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 76 Issue 8 Pg. 17-9 ( 2013) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 24228483 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cardiotonic Agents
• Guanidines
• Pyrazoles
• Troponin I
• zoniporide

Topics

• Animals
• Arrhythmias, Cardiac (blood, etiology, physiopathology, prevention & control)
• Cardiotonic Agents (pharmacology)
• Disease Models, Animal
• Female
• Guanidines (pharmacology)
• Myocardial Reperfusion Injury (blood, drug therapy, pathology, physiopathology)
• Myocardium (metabolism, pathology)
• Necrosis
• Pyrazoles (pharmacology)
• Rats
• Troponin I (blood)