Abstract | BACKGROUND: METHODS: We evaluated the serum LBP, inflammatory cytokines, and the relationship between LBP concentrations, functional liver reserve and outcomes in 58 critically ill cirrhotic patients with severe sepsis. RESULTS: The serum LBP levels were significantly higher in 28-day survivors, while the interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were significantly higher in non-survivors. We analyzed the receiver operating characteristic (ROC) curve to determine the cut-off point for LBP to predict 28-day mortality. The cumulative rates at 28 days were 58.3% versus 16.7% for the high LBP group (>46 ng/mL) and low LBP group (<46 ng/mL) (p < 0.001). The high-LBP group had significantly lower INR, Child-Pugh, Model for End-stage Liver Disease (MELD) scores and TNF-α level. Meanwhile, the LBP levels were inversely correlated with INR, and Child-Pugh, MELD and sequential organ failure assessment (SOFA) scores. CONCLUSION: The concentration of LBP is associated inversely with disease severity scores and outcomes in critically ill cirrhotic patients with severe sepsis.
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Authors | Yi-Yuan Chen, Jau-Min Lien, Yun-Shing Peng, Yung-Chang Chen, Ya-Chung Tian, Ji-Tseng Fang, Hsing-Chih Huang, Pang-Chi Chen, Chih-Wei Yang, Cheng-Shyong Wu, Ming-Hung Tsai |
Journal | Journal of the Chinese Medical Association : JCMA
(J Chin Med Assoc)
Vol. 77
Issue 2
Pg. 68-74
(Feb 2014)
ISSN: 1728-7731 [Electronic] Netherlands |
PMID | 24225281
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013. Published by Elsevier B.V. |
Chemical References |
- Acute-Phase Proteins
- Carrier Proteins
- Cytokines
- Membrane Glycoproteins
- lipopolysaccharide-binding protein
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Topics |
- Acute-Phase Proteins
- Aged
- Carrier Proteins
(blood)
- Critical Illness
- Cytokines
(blood)
- Female
- Humans
- Liver Cirrhosis
(blood)
- Male
- Membrane Glycoproteins
(blood)
- Middle Aged
- Sepsis
(complications)
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