According to the World Health Organization, Complementary and
alternative medicine (CAM) is a comprehensive term referring to traditional medical treatments and various forms of indigenous medicines, also known as indigenous or
folk medicine.
Cancer patients often use CAM in the form of nutritional supplements, psychological techniques and natural medical approaches in the place of or in parallel to conventional medicine. The present study aimed to determine if
Chitosan can inhibit lung
metastasis and
hepatoma formation, by studying xenograft of B16F10
melanoma cells in C57BL/6 mice and of Smmu 7721 cells in SCID mice, respectively. For the lung
metastasis model, after a five-week treatment, the survival rates of B6 mice were 15% for the control group and 35%, 20%, 45% and 40% for the 320,000 kDa, 173,000 kDa, 86,000 kDa and 8,000 kDa molecular-weight treatment groups, respectively.
Chitosan treatment dramatically increased lifespan and inhibited
tumor metastasis especially in treatment groups of the low-molecular weight compound. For the
hepatoma growth model, the size of the liver
tumor mass was approximately >14 mm in the control group. In comparison to the control group, the
tumor mass grew slowly with
Chitosan treatment, especially at the low-molecular weight treatment group.
Chitosan slowed-down the rate of
tumor growth but did not inhibit
tumor formation. Data presented herein demonstrate that
Chitosan has anticancer effects and thus further study of the substance is warranted to examine for mechanisms of action and optimal dosage.