Antimutagenic effect of Origanum majorana L. essential oil against prallethrin-induced genotoxic damage in rat bone marrow cells.

Abstract

This study aimed to investigate the genotoxic and cytotoxic potential of prallethrin in rat bone marrow cells and the protective effect of Origanum majorana L. essential oil (EO). Our results demonstrated that prallethrin at dose 64.0 mg/kg body weight (b.wt.) (1/10 LD50), has a clastogenic/genotoxic potential as shown by the high percentage of chromosomal aberration (CA) and micronucleus (MN) in the bone marrow cells of male rats, whereas the combined treatment of prallethrin and O. majorana EO resulted in the reduction of the CA (54.54%). The combined treatment also reduced the micronuclei formation significantly. In conclusion, prallethrin can be considered clastogenic/genotoxic and may carry a risk to human health. The study revealed the antigenotoxic and anticytotoxic potential of O. majorana EO against prallethrin-induced genotoxic and cytotoxic effects in rat bone marrow cells.

• Authors: Abdel-Tawab H Mossa, Amel A Refaie, Amal Ramadan, Jalloul Bouajila
• Journal: Journal of medicinal food (J Med Food) Vol. 16 Issue 12 Pg. 1101-7 (Dec 2013) ISSN: 1557-7600 [Electronic] United States
• PMID: 24195751 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimutagenic Agents
• Mutagens
• Oils, Volatile
• Plant Extracts
• Pyrethrins
• d,d-T80-prallethrin

Topics

• Animals
• Antimutagenic Agents (pharmacology)
• Bone Marrow Cells (drug effects)
• DNA Damage (drug effects)
• Dose-Response Relationship, Drug
• Male
• Mutagens (toxicity)
• Oils, Volatile (pharmacology)
• Origanum (chemistry)
• Plant Extracts (pharmacology)
• Pyrethrins (toxicity)
• Rats
• Rats, Wistar