Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: MATERIALS AND METHODS:
Type 2 diabetes was induced in 140 rats by feeding with HFD and high sugar water for 6 weeks and single injection of STZ (30mg/kg, intraperitoneally). CP ethanol extract (CPEE) and aqueous extract (CPAE) at three doses at 2, 4 and 8 g/kg/day were orally administered once daily for four weeks. Blood glucose, serum insulin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), free fatty acid (FFA), total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol ( LDL-C), high density lipoprotein-cholesterol (HDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), blood urea nitrogen (BUN), creatinine (CREA) and glycated serum protein (GSP) were examined. The content of total flavonoids and polysaccharides in CPEE and CPAE were assayed by ultraviolet spectrophotometry. RESULTS: Both CPEE and CPAE increased OGTT, ITT, HDL-C, SOD and GSH-Px, while they decreased FFA, TC, TG, LDL-C, MDA, BUN, CREA and GSP. The amount of total flavonoids was found in CPEE (30.41 mg/g extract), followed by CPAE (6.75 mg/g extract). Similarly, the polysaccharides content (4.13 mg/g extract) was observed in CPAE, while absent in CPEE. CONCLUSIONS:
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Authors | Qingqing Wang, Cuihua Jiang, Shengzuo Fang, Junhu Wang, Yun Ji, Xulan Shang, Yicheng Ni, Zhiqi Yin, Jian Zhang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 150
Issue 3
Pg. 1119-27
(Dec 12 2013)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 24184190
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Published by Elsevier Ireland Ltd. |
Chemical References |
- Antioxidants
- Blood Glucose
- Hypoglycemic Agents
- Hypolipidemic Agents
- Insulin
- Lipids
- Plant Extracts
- Malondialdehyde
- Glutathione Peroxidase
- Superoxide Dismutase
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Blood Glucose
(analysis)
- Diabetes Mellitus, Experimental
(blood, drug therapy)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Diet, High-Fat
- Glutathione Peroxidase
(blood)
- Hyperlipidemias
(blood, drug therapy)
- Hypoglycemic Agents
(therapeutic use)
- Hypolipidemic Agents
(therapeutic use)
- Insulin
(blood)
- Juglandaceae
- Lipids
(blood)
- Male
- Malondialdehyde
(blood)
- Phytotherapy
- Plant Extracts
(therapeutic use)
- Plant Leaves
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(blood)
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