Abstract | BACKGROUND: METHODS: RESULTS: Women in the highest tertile of serum HMW adiponectin levels were associated with a statistically significant decreased risk for breast cancer compared with women in the lowest tertile [odds ratio (OR), 0.09; 95 % confidence interval (CI) 0.03-0.33]. This association was observed in postmenopausal women (OR 0.06; 95 % CI 0.01-0.28), but not in premenopausal women. The observed associations were independent of possible effects of insulin, body mass index, and known risk factors for breast cancer. Serum isoflavones and insulin levels were not associated with breast cancer risk. CONCLUSIONS:
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Authors | Machiko Minatoya, Goro Kutomi, Sumiyo Asakura, Seiko Otokozawa, Yukiko Sugiyama, Hirofumi Ohnishi, Hiroshi Akasaka, Tetsuji Miura, Mitsuru Mori, Koichi Hirata |
Journal | Breast cancer (Tokyo, Japan)
(Breast Cancer)
Vol. 22
Issue 5
Pg. 452-61
(Sep 2015)
ISSN: 1880-4233 [Electronic] Japan |
PMID | 24166746
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Insulin
- Isoflavones
- daidzein
- Genistein
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Topics |
- Adiponectin
(blood, chemistry)
- Adult
- Asian People
- Body Mass Index
- Breast Neoplasms
(blood, etiology)
- Case-Control Studies
- Female
- Genistein
(blood)
- Humans
- Insulin
(blood)
- Isoflavones
(blood)
- Middle Aged
- Molecular Weight
- Postmenopause
- Premenopause
- Risk Factors
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