Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population.

Abstract

Helicobacter pylori-specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six H. pylori-specific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow-up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 H. pylori-positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of H. pylori recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, p < 0.0001) or intestinal metaplasia (IM, p = 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI = 1.42-4.55) for IM and 2.38 (95% CI = 1.05-5.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI = 1.27-6.59) and 2.20 (95% CI = 1.33-3.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (p(for) trend = 0.0003). This population-based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high-risk H. pylori strains, which are related to the development of GC in a Chinese high-risk population, and recomLine test might serve as a tool for risk stratification.

• Authors: Kai-Feng Pan, Luca Formichella, Lian Zhang, Yang Zhang, Jun-Ling Ma, Zhe-Xuan Li, Cong Liu, Yu-Mei Wang, Gereon Goettner, Kurt Ulm, Meinhard Classen, Wei-Cheng You, Markus Gerhard
• Journal: International journal of cancer (Int J Cancer) Vol. 134 Issue 9 Pg. 2118-25 (May 01 2014) ISSN: 1097-0215 [Electronic] United States
• PMID: 24155048 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 UICC.

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Bacterial Proteins
• Chaperonin 60
• cagA protein, Helicobacter pylori

Topics

• Antibodies, Bacterial (blood)
• Antigens, Bacterial (immunology)
• Asian People
• Bacterial Proteins (immunology)
• Chaperonin 60 (immunology)
• Helicobacter Infections (complications, immunology)
• Helicobacter pylori (immunology)
• Humans
• Precancerous Conditions (immunology, microbiology, pathology)
• Randomized Controlled Trials as Topic
• Seroepidemiologic Studies
• Stomach Neoplasms (immunology, microbiology, pathology)