Metaplasia

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3153 relevant articles (41 outcomes, 282 trials/studies) found for this Disease

Description: A condition in which there is a change of one adult cell type to another similar adult cell type.

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Metaplasia: 3153

Pathologic Neovascularization: 413

Related Diseases

1.	Adenocarcinoma
2.	Stomach Neoplasms (Stomach Cancer)
3.	Gastritis
4.	Hyperplasia
5.	Inflammation

Experts

1.	Goldenring, James R: 7 articles (12/2007 - 03/2002)
2.	Yamaguchi, Hirokazu: 5 articles (12/2007 - 03/2002)
3.	Lee, Jeffrey R: 5 articles (08/2004 - 03/2002)
4.	Moreira-Dias, Luís: 3 articles (09/2008 - 09/2004)
5.	Dinis-Ribeiro, Mário: 3 articles (09/2008 - 09/2004)
6.	Holtzman, Michael J: 3 articles (03/2008 - 02/2006)
7.	Tatematsu, Masae: 3 articles (12/2007 - 03/2004)
8.	Kaminishi, Michio: 3 articles (12/2007 - 03/2002)
9.	David, Leonor: 3 articles (05/2006 - 03/2002)
10.	Younes, Mamoun: 3 articles (09/2004 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Metaplasia:

1.	AntralIBA 03/01/2008 - "AIMS: To report three children displaying gastric metaplasia antral pyloric type of the small bowel mucosa. " 11/01/2007 - "Abnormal cellular maturation (mucocyte metaplasia) in the vagina was observed at 625 and 1,250 ppm, and abnormal ovarian antral follicles were observed at 1,250 ppm. In males, aberrant or delayed spermatogenesis in the seminiferous tubules relative to controls was observed at 1,250 ppm. Histologic evaluation indicated a deficit of sperm in the epididymis at 625 and 1,250 ppm relative to controls, although testicular spermatid head counts and epididymal spermatozoa counts did not show significant differences from controls at these exposure concentrations. " 03/01/2007 - "In all of the forms of antral metaplasia. " 03/01/2007 - "METHODS: We collected 43 pieces of colecistectomy whit antral metaplasia, intestinal metaplasia and displasia. " 12/01/2006 - "Intestinal metaplasia at both antral and body sites had negative relationships with acid output with CC = 0.23 and 0.20, respectively. " Order ALL the reference details at left...
2.	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/01/1988 - "Our findings suggest that retinoic acid ointment is effective in treating severe squamous metaplasia in cicatrizing diseases of the conjunctiva. " 10/01/1996 - "This trial tested the effects of 6 months of treatment with 13-cis retinoic acid (13cRA) on bronchial metaplasia. " 10/01/1988 - "In a prospective, double-masked clinical study, the authors evaluated the efficacy and safety of topically applied tretinoin ophthalmic ointment (0.01%) versus placebo in the treatment of squamous metaplasia associated with various ocular surface disorders involving dry eyes. " 07/01/1998 - "Its expression was found at all stages of differentiation of the human epidermis and was reduced but not suppressed when oral metaplasia of reconstructed epidermis was induced by retinoic acid. " 09/01/1996 - "Topical retinoic acid has proved to be of variable benefit in a number of dry eye disorders of disparate aetiology, in which squamous metaplasia with keratinization of ocular epithelium is present. " Order ALL the reference details at left...
3.	Folic Acid (Vitamin M)FDA LinkGeneric 04/15/1993 - "It was suggested that the epithelial hyperplasia and metaplasia of respiratory tract induced by MCA can be suppressed by the administration of folic acid." 09/30/1992 - "Evidence for the possible existence of localized folate deficiencies in the aerodigestive tract includes lower circulating folate levels in smokers as compared with nonsmokers; yet lower circulating levels in smokers with bronchial metaplasia; lower folate levels in scrapings of the buccal mucosa of smokers than non-smokers; apparent improvement in bronchial atypical metaplasia in smokers supplemented with folic acid; lower erythrocyte folate levels and higher prevalence of cellular features compatible with folate deficiency in geographic areas and individuals in South Africa at high risk for esophageal cancer; and a trend toward a lower prevalence of colonic dysplasia in ulcerative colitis patients who use folic acid supplements. " 01/20/1996 - "Numerous clinical studies have pointed to an association between folate status in adults and both the occurrence of cancer and the premalignant changes, cervical dysplasia, bronchial metaplasia, and colorectal adenomas. " 03/11/1988 - "Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. " 08/01/1994 - "The purpose of this study was to observe the effects of folate and vitamin B12 on bronchial squamous metaplasia with cellular atypia, known to be a precancerous change, in heavy smokers. " Order ALL the reference details at left...
4.	Pepsinogen A (Pepsinogen)IBA 10/01/2007 - "Improved endoscopic examination using magnification chromoendoscopy together with non-invasive functional assessment with pepsinogen serum levels are accurate in the diagnosis of intestinal metaplasia (extension) and minute dysplastic lesions. " 10/01/2007 - "Endoscopic examination and pepsinogen serum level measurement on a yearly basis would cost 1868 euros per QALY for patients with extensive intestinal metaplasia. " 10/01/2007 - "Seven cases of dysplasia were diagnosed during follow-up, all among patients with incomplete intestinal metaplasia at baseline, six of whom had extensive (pepsinogen I to II ratio <3) incomplete intestinal metaplasia. " 01/01/2005 - "Almost all remnant pyloric glands for SIM were negative for pepsinogen I. These facts indicate that SIM in the body originates in a proliferative zone that shifted downward to an area near the bottom of the tubule, with atrophic pyloric glands originating from pseudopyloric gland metaplasia." 01/01/2005 - "2) Intestinal metaplasia types II and III have been shown to have a higher rate of progression to low-grade dysplasia than type I. 3) With regard to screening in asymptomatic individuals, serum pepsinogen may represent an alternative to conventional fluoroscopy methods. " Order ALL the reference details at left...
5.	RetinoidsIBA 02/01/2001 - "Retinoids are critical for differentiation of columnar epithelial cells and for preventing metaplasia of these cells into stratified squamous epithelial cells, in which tight junctions (TJs) are essentially absent. " 08/01/1998 - "The use of two retinoids (Ro40-6055, 8 x 10(-3) microM, or CD437, 7.7 x 10(-2) microM) that are believed to act, respectively, as a RARalpha- or a RARgamma-specific agonist showed that both these receptors can initiate a metaplasia. " 09/01/1993 - "Similar to the induction of squamous metaplasia in vivo, culture of rabbit tracheal cells in the absence of retinoids results in squamous differentiation and expression of cornifin. " 05/01/1989 - "The bony metaplasia induced by RAc was similar to the pathologic changes caused by other retinoids. " 06/01/1984 - "Tracheal organ cultures from retinoid-deficient hamsters have been used successfully to indicate the potency of synthetic retinoids by monitoring the reversal of squamous metaplasia. " Order ALL the reference details at left...
6.	MucinsIBA 01/01/1989 - "The IPC showed a considerable improvement of squamous metaplasia in the mucin less than - greater than group, by an average of 4.3 points (from 6.2 points before treatment to 1.9 points). " 01/01/2006 - "The present study indicates that the MUC2 mucin expression pattern is a reliable marker of intestinal metaplasia, which appears in the context of H. " 01/01/2005 - "This study used mucin immunohistochemistry to investigate differences in the properties of intestinal metaplasia between the antrum and body of the stomach in 28 resected specimens. " 12/01/1999 - "The study has demonstrated aberrant expression of MUC2 (an intestinal mucin) in Barrett's metaplasia and this expression is lost when the cells become dysplastic. " 05/01/1996 - "The observation in this study suggests that those tumours which secrete neutral and mixed mucin probably arise from gastric epithelium, neck cells of gastric glands or colonic metaplasia. " Order ALL the reference details at left...
7.	AntibodiesIBA 04/01/2007 - "In immature metaplasia all proliferating cells were immunoreactive with antibodies to CK17 and p63, while p16 was negative. " 04/01/2007 - "MATERIAL AND RESULTS: Seventy-five cervical biopsy specimens, curettings and cone excisions containing varying proportions of dysplasia and metaplasia and 20 cases regarded as AIM were analysed immunohistochemically with antibodies to CK17, p16 and p63. " 06/01/2003 - "Specific antibodies were measured, and histologic lung sections were examined for goblet cell metaplasia. " 01/01/2003 - "Use of Helicobacter pylori-specific antibodies in the evaluation of intestinal metaplasia and gastric dysplasia." 04/01/2002 - "A panel consisting of antibodies against keratinocytes (CKs) 5, 13, 18, and 20 and markers of squamous metaplasia (CKs 7, 8, and 14) was used to probe normal urothelium and 30 UPs collected during a period of five years. " Order ALL the reference details at left...
8.	Messenger RNA (mRNA)IBA 10/01/2009 - "On the other hand, endogenous Cdx1 mRNA and protein were expressed in the intestinal metaplasia of the Cdx2-transgenic mouse stomach. " 10/01/2009 - "However, endogenous Cdx2 mRNA was not expressed in the intestinal metaplasia of the Cdx2-transgenic mouse stomach. " 09/01/2006 - "Histological examination indicated that A2 induced no goblet cell hyper/metaplasia, whereas the Line 19 induced goblet cell expansion and significant increases in gob5 and MUC5AC mRNA and protein levels in vivo. " 05/28/2006 - "In gastric samples, some with intestinal metaplasia, the levels of PEPT1 and Cdx2 mRNA were highly correlated. " 08/21/2005 - "In addition, 3 of 23 (13%) patients with atrophic mucosa and 6 of 35 (17%) patients with intestinal metaplasia showed increased COX-2 mRNA expression. " Order ALL the reference details at left...
9.	Proteins (Proteins, Gene)IBA 03/01/1992 - "Our findings confirm the high degree of homology between mammalian CK, and on the basis of those findings, we suggest that CK proteins provide a set of markers valuable for the characterization of normal and neoplastic feline tissues and for studies of squamous metaplasia." 08/01/2009 - "RESULTS: Adipo-R1 and Adipo-R2 immunoexpression was found in 22/49 GCs and in intestinal metaplasia areas near the tumours, whereas only slight immunoreactivity for these proteins was found in adjacent normal gastric epithelium. " 01/01/2008 - "Determination of these proteins does not allow discrimination between different degrees of neoplasia or between esophageal intestinal metaplasia and cardiac mucosa." 12/01/2007 - "The different structures containing tight junction proteins in epidermal and other stratified epithelial cells, including squamous cell metaplasia." 04/01/2005 - "Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia. " Order ALL the reference details at left...
10.	Estrogens (Estrogen)FDA Link 09/01/2002 - "OBJECTIVE: To determine if testing for HPV is useful in the management of patients with atypical squamous metaplasia (ASM) and to evaluate a small group of patients with atypical squamous cells in the setting of an atrophic cellular profile (estrogen test [ESTT]). " 01/01/1989 - "Estrogens induce malpighian metaplasia of the endocervical junction in female rats immunohistochemistry study." 11/01/1986 - "The results of the present study have shown that the response of the normal uterine cervix to estrogenic influence is heterogeneous in different cervical cell types and in different sites within the same cell layer; during the normal menstrual cycle the capability of response of the cervical cells to variations of estrogen levels is limited when compared with the endometrium; and during pregnancy and in the process of indirect squamous metaplasia some of the cervical cells seem to be very reactive to estrogenic stimulation. " 01/01/2005 - "However, treatment of intact and castrated dogs with estrogen resulted in squamous metaplasia with intense COX-2 expression observed in both squamous epithelial cells and in cells of acini without metaplasia. " 06/01/2002 - "Specifically, estrogens have been shown to influence the development of the fetal and neonatal rodent prostate and to induce a pathognomonic change, termed squamous metaplasia, in the developing and adult prostate. " Order ALL the reference details at left...

Therapies and Procedures

1.	Ablation Techniques 01/01/2005 - "Finally, several studies have reported promising results with the endoscopic treatment of Barrett's metaplasia and early neoplasia using ablation techniques or endoscopic resection modalities. " 06/01/2009 - "Likewise, this technique may be the therapeutic option in patients with high grade dysplasia and adenocarcinoma, although its application must be complemented with ablation techniques such as radiofrequency to eliminate the residual Barrett's metaplasia. " 12/01/2008 - "Recent studies suggest that this ablation technique is highly effective in removing Barrett's mucosa and its associated dysplasia without the known drawbacks of photodynamic therapy or argon plasma coagulation, such as esophageal stenosis and subsquamous foci of intestinal metaplasia (also known as "buried Barrett"). " Order ALL the reference details at left...
2.	Chemoprevention 02/01/1999 - "These studies demonstrate the ability to induce protective GST-pi in Barrett's metaplasia and may suggest a mechanism for future chemoprevention studies in patients with this type of epithelium, which is at high risk for malignant degeneration." 12/06/2000 - "METHODS: A randomized, controlled chemoprevention trial was conducted in subjects with confirmed histologic diagnoses of multifocal nonmetaplastic atrophy and/or intestinal metaplasia, two precancerous lesions. " 10/01/1996 - "This study demonstrated that increased EGFr expression is a biomarker of bronchial metaplasia, but it did not support the hypothesis that EGFr is a biomarker of retinoid response in lung cancer chemoprevention trials." 06/01/1995 - "Studies of chemoprevention in lung cancer have included trials to reverse premalignant lesions such as sputum atypia or squamous metaplasia of the bronchial epithelium. " 06/01/2007 - "Search terms included: Barrett's (o)esophagus, intestinal metaplasia, (o)esophageal adenocarcinoma, molecular changes, genetic changes, pathogenesis, chemoprevention, therapeutic strategies and treatment. " Order ALL the reference details at left...
3.	Gastrectomy 10/01/2002 - "CONCLUSIONS: LRYGBP with remnant gastrectomy is a safe and cost-effective treatment for morbidly obese patients with focal intestinal metaplasia of the stomach." 09/01/2005 - "The aim of this study was to detect esophageal columnar metaplasia after total gastrectomy with esophagojejunostomy, a condition of enteric, but nonacidic reflux. " 12/01/2005 - "BACKGROUND: Extensive intestinal metaplasia (EIM) has been reported in gastrectomies from patients dwelling in the Pacific and Atlantic basins.AIMS: To compare all the results in an attempt to explain the findings.Method" 09/01/2005 - "METHODS: In a prospective study, patients with a history of total gastrectomy and esophagojejunostomy were investigated for the presence of columnar metaplasia in the remnant esophagus. " 09/01/2005 - "Small-bowel metaplasia arising in the remnant esophagus after esophagojejunostomy--a [corrected] prospective study in patients with a history of total gastrectomy." Order ALL the reference details at left...
4.	Aftercare (After-Treatment) 06/01/2000 - "pylori and cocci density was found before and after treatment in patients with intestinal metaplasia (p=0.020). " 06/01/2000 - "RESULTS: Whereas acute epithelial damage was quickly repaired, some of the local responses to bacteria, e.g., lymphoid aggregates and intestinal metaplasia, persisted after treatment. " 08/01/1998 - "Nevertheless, the highest degrees and ratios of metaplasia were only obtained after treatment with the CD367 RAR panagonist, or with either Ro40-6055 or CD437 at a concentration sufficient to allow the activation of the three RAR, suggesting that RARbeta activation is required for a metaplasia of all vibrissae." 02/01/1995 - "The median extent of gastric metaplasia at the start of treatment and 6-18 months (median 10) after treatment was compared in the two groups. " 10/01/1986 - "After treatment, clinical improvements were correlated with the reversal of squamous metaplasia as evidenced by the impression cytology technique. " Order ALL the reference details at left...
5.	Photochemotherapy (Photodynamic Therapy) 11/01/1999 - "Photodynamic therapy using 5-aminolaevulinic acid for oesophageal adenocarcinoma associated with Barrett's metaplasia." 01/01/2000 - "CONCLUSIONS: In this selected group of patients with high-grade dysplastic Barrett's esophagus or adenocarcinoma referred for photodynamic therapy, gastric metaplasia of the proximal esophagus was found in nearly one third. " 10/01/2004 - "Barrett's metaplasia is replaced by a squamous epithelium when acid reflux is well controlled and the epithelium is physically destroyed by ablation with argon plasma coagulation or photodynamic therapy. " 10/01/1999 - "Because of the increasing incidence of these latter, many endoscopic methods such as argon plasma coagulation, photodynamic therapy or endoscopic mucosal resection are now in evaluation in order to eradicate Barrett's oesophagus or to treat dysplasia and early cancers arising from this metaplasia. " 12/01/2008 - "Recent studies suggest that this ablation technique is highly effective in removing Barrett's mucosa and its associated dysplasia without the known drawbacks of photodynamic therapy or argon plasma coagulation, such as esophageal stenosis and subsquamous foci of intestinal metaplasia (also known as "buried Barrett"). " Order ALL the reference details at left...

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