Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: Thirty patients with type 2 diabetes and documented CVD who had been treated with insulin and/or SU underwent 5 days of monitoring with a continuous glucose measurement system along with parallel electrocardiogram recording for monitoring of ventricular arrhythmias. Twelve age-matched patients with documented CVD who received treatment with metformin and/or dipeptidyl peptidase-4 inhibitor served as the control group. Patients were receiving stable treatment, and were instructed to notice symptoms of arrhythmias and hypoglycemia, respectively. RESULTS: We observed a high incidence of asymptomatic severe episodes of hypoglycemia (<3.1 mmol/L) in patients receiving treatment with insulin and/or SU, whereas severe hypoglycemia did not develop in any of the control subjects. Patients with severe hypoglycemia (n = 12) had a higher number of severe ventricular arrhythmias (patients with versus without severe hypoglycemia, respectively: ventricular couplets 41.7 ± 81.8 vs. 5.5 ± 16.7; ventricular tachycardia 1.0 ± 1.9 vs. 0.1 ± 0.3). No direct correlation could be found among different variables of glucose profile, corrected QT interval, and ventricular arrhythmias. CONCLUSIONS: Our results suggest that severe episodes of hypoglycemia are associated with an increased risk of severe ventricular arrhythmias.
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Authors | Annett Stahn, Frank Pistrosch, Xenia Ganz, Madlen Teige, Carsta Koehler, Stefan Bornstein, Markolf Hanefeld |
Journal | Diabetes care
(Diabetes Care)
Vol. 37
Issue 2
Pg. 516-20
(Feb 2014)
ISSN: 1935-5548 [Electronic] United States |
PMID | 24041680
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Arrhythmias, Cardiac
(epidemiology)
- Diabetes Mellitus, Type 2
(drug therapy, epidemiology)
- Female
- Humans
- Hypoglycemia
(epidemiology)
- Incidence
- Insulin
(therapeutic use)
- Male
- Middle Aged
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