Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart.

Abstract

Barker's concept of 'foetal programming' proposes that intrauterine growth restriction (IUGR) predicts complex metabolic diseases through relationships that may be further modified by the postnatal environment. Dietary restriction and deficit in methyl donors, folate, vitamin B12, and choline are used as experimental conditions of foetal programming as they lead to IUGR and decreased birth weight. Overfeeding and deficit in methyl donors increase central fat mass and lead to a dramatic increase of plasma free fatty acids (FFA) in offspring. Conversely, supplementing the mothers under protein restriction with folic acid reverses metabolic and epigenomic phenotypes of offspring. High-fat diet or methyl donor deficiency (MDD) during pregnancy and lactation produce liver steatosis and myocardium hypertrophy that result from increased import of FFA and impaired fatty acid β-oxidation, respectively. The underlying molecular mechanisms show dysregulations related with similar decreased expression and activity of sirtuin 1 (SIRT1) and hyperacetylation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). High-fat diet and overfeeding impair AMPK-dependent phosphorylation of PGC-1α, while MDD decreases PGC-1α methylation through decreased expression of PRMT1 and cellular level of S-adenosyl methionine. The visceral manifestations of metabolic syndrome are under the influence of endoplasmic reticulum (ER) stress in overnourished animal models. These mechanisms should also deserve attention in the foetal programming effects of MDD since vitamin B12 influences ER stress through impaired SIRT1 deacetylation of HSF1. Taken together, similarities and synergies of high-fat diet and MDD suggest, therefore, considering their consecutive or contemporary influence in the mechanisms of complex metabolic diseases.

• Authors: Jean-Louis Guéant, Rania Elakoum, Olivier Ziegler, David Coelho, Eva Feigerlova, Jean-Luc Daval, Rosa-Maria Guéant-Rodriguez
• Journal: Pflugers Archiv : European journal of physiology (Pflugers Arch) Vol. 466 Issue 5 Pg. 833-50 (May 2014) ISSN: 1432-2013 [Electronic] Germany
• PMID: 23999818 (Publication Type: Journal Article, Review)

Chemical References

• Fatty Acids

Topics

• Animals
• Epigenesis, Genetic
• Fatty Acids (metabolism)
• Female
• Fetal Development
• Fetal Heart (embryology, metabolism, physiology)
• Fetal Nutrition Disorders (metabolism)
• Genome, Human
• Humans
• Liver (embryology, metabolism, physiology)
• Nutrigenomics