Abstract | INTRODUCTION: The aim of the present study was to evaluate the effect of triiodothyronine (T3) administration in a porcine model of hemorrhagic shock due to liver surgery, in terms of hemodynamic stability, acid-base status, and hepatic injury markers. MATERIALS AND METHODS:
Hemorrhagic shock was induced in swine by left lobe liver resection and allowed bleeding to a mean arterial pressure of 35-40 mmHg for 40 min. Animals were randomly assigned into a sham group (n = 5), a fluid-resuscitated group (n = 7), and a fluid plus T3-resuscitated group (n = 7). T3 was given by continuous intravenous infusion from the beginning of the experiment. After the 40 min of shock animals were resuscitated with the aim of restoring mean arterial pressure (±10% from baseline). Resuscitation lasted for 1 hr and then swine were followed for another 460 min (total 6 hr). Blood loss, hamodynamic parameters, fluids administered, acid-base status, and liver enzymes were measured. RESULTS: Blood loss was similar in both groups. Animals treated with T3 required less fluids than swine resuscitated with crystalloids and colloids only (N/S 0.9%: 1071 ± 189 ml vs. 2429 ± 535 ml, Voluven 6%: 550 ± 96 ml vs. 1000 ± 289 ml, p < .05), plus they were less acidotic at the end of the observing period (7.38 ± 0.08 vs. 7.26 ± 0.12, p < .05). Tachycardia was not associated with T3 administration. Hepatic enzymes did not exhibit differences between groups. CONCLUSION: Our study demonstrates the beneficial impact of T3 administration during controlled hemorrhagic shock and resuscitation. Animals resuscitated with T3 necessitate less amounts of fluids to maintain hemodynamic stability and acid-base status. Moreover, T3 administration does not seem to aggravate blood loss or harm the hepatic tissue.
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Authors | Iosifina Karmaniolou, Constantinos Pantos, Nikolaos Orfanos, Anastasios Mylonas, Kassiani Theodoraki, Chryssoula Staikou, Eirini Stergiou, Georgia Kostopanagiotou, Vassilios Smyrniotis, Nikolaos Arkadopoulos |
Journal | Journal of investigative surgery : the official journal of the Academy of Surgical Research
(J Invest Surg)
Vol. 26
Issue 6
Pg. 305-11
(Dec 2013)
ISSN: 1521-0553 [Electronic] United States |
PMID | 23978248
(Publication Type: Journal Article)
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Chemical References |
- Crystalloid Solutions
- HES 130-0.4
- Hydroxyethyl Starch Derivatives
- Isotonic Solutions
- Triiodothyronine
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Topics |
- Acid-Base Equilibrium
- Animals
- Crystalloid Solutions
- Fluid Therapy
- Hemodynamics
- Hydroxyethyl Starch Derivatives
(therapeutic use)
- Isotonic Solutions
(therapeutic use)
- Liver
(injuries, surgery)
- Male
- Resuscitation
- Shock, Hemorrhagic
(drug therapy)
- Swine
- Triiodothyronine
(therapeutic use)
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